[9]Reitman ML, Chu X, Cai X, et al. Rifampin's acute inhibitory and chronic inductive drug interactions: experimental and model-based approaches to drug-drug interaction trial design[J]. Clin Pharmacol Ther. 2011. 89(...
Drug interactionsPharmacokineticsAntiretroviral therapyTherapy for human immunodeficiency virus (HIV) and chronic hepatitis C has evolved over the past decade,resulting in better control of infection and clinical outcomes;however,drug-drug interactions remain a significant hazard.Joint recommendations from the ...
在我国TB患者中HCV感染的比例约1.6%~6.7%;而在HCV感染者中,TB合并HCV感染的比例也有0.7%[3],其比例低可能与TB检查方法敏感性低和主动筛查者少有关。在TB合并HCV感染者中,针对抗TB药物与抗HCV药物之间的相互作用(drug-drug interactions,D...
In contrast, sofosbuvir and daclatasvir based antiviral therapy are not expected to lead to clinically significant drug-drug interactions in LT recipients but confirmatory studies are needed. Liver transplant recipients may also be at increased risk of developing drug induced liver injury (DILI). ...
Virus-drug interactions-molecular insight into immunosuppression and HCV. Nat Rev Gastroenterol Hepatol 2012; 9: 355-362.Pan Q, Tilanus HW, Metselaar HJ, Janssen HL, van der Laan LJ. Virus-drug interactions--molecular insight into im- munosuppression and HCV. Nat Rev Gastroenterol Hepatol 2012...
Although drug-drug interactions constitute only a small proportion of adverse drug reactions, they are important because they are often predictable and the... RM Seymour,PA Routledge - 《Drugs & Aging》 被引量: 439发表: 1998年 Prevalence of potential drug–drug interactions in cancer patients tre...
信源:Chen Hua Liu, et al. Comorbidities, concomitant medications and potential drug‐drug interactions with interferon‐free direct-acting antiviral agents in hepatitis C patients in Taiwan. First published: 25 October 2018 https://doi.org/10.1111/apt.15011....
对于肾移植受者中HIV/HCV共感染的特殊人群, DDI的监测必须包括抗逆转录病毒药物,并通过肾病科医师、肝病科医师和HIV方面专家以多学科方式指导DAA方案和(或)抗逆转录病毒药物的应用。因此,本声明强烈推荐参考www.hep-druginteractions.org和www.hiv-druginteractions.org的药物相互作用图表。
Despite ample data regarding the pharmacokinetic interactions between DAAs and ART in the general population with HIV/HCV coinfection, there have been no studies evaluating important drug interactions during pregnancy when pharmacokinetics are impacted by physiologic changes [69,70,71]. We must chart a...
由于药物种类和其参与药物代谢的酶种类繁多,临床评估药物间DDI极为困难。由英国利物浦大学创建的网页(http://www.hep-druginteractions.org),可快捷检索DAAs与合用药物之间是否存在相互作用。 四、DAAs随访监测 在DAAs治疗过程中,推荐治疗第4周时检测HCV...