3-Step test algorithmHIVHIV testing strategyTesting algorithmHIV-1/2 testing is the first step in ensuring HIV-infected individuals are diagnosed and appropriately managed. The impact of suboptimal HIV-1/2 test
目前常用的HIV核酸检测试剂盒主要是基于转录介导恒温扩增技术如Aptima HIV-1 RNA定量和定性试剂盒,和基于实时定量PCR技术如Roche Cobas HIV-1 RNA定量和定性试剂盒、Abbott RealTime HIV-1 RNA定量和定性试剂盒 、Cepheid Xpert HIV-1 RNA定量和定性试剂盒等(见表2)。 核酸靶向基因检测:核酸靶向基因检测常用的方法...
HIV-Testing Algorithm and Exclusion criteria Survey 1.Inge, KroidlPetra, ClowesWolfram, MwalongoLucas, MagangaLeonard, MabokoArne, L. KroidlChristof, GeldmacherHarun, MachibyaMichael, HoelscherElmar, Saathoff
et al. Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm. J. Virol. 83, 7337–7348 (2009). Article CAS PubMed PubMed Central Google...
(Accession numbers: Table S3) obtained from the Los Alamos database (https://www.hiv.lanl.gov) and then the nucleotide alignments were used to build phylogenetic tree for further HIV-1 subtyping by MEGA 7.0.2 (https://www.megasoftware.net) using the neighbor-joining algorithm based on ...
HIV testing was performed at screening, study enrollment (Visit 1) and every three months thereafter using whole blood from finger-stick for RDT and plasma EDTA for IA when necessary. Two RDT were used in the HIV diagnostic algorithm (Fig. 1): Abbott Determine HIV-1/2 Ag/Ab Combo (DET-...
The HTS counsellor in the study team will provide pre- and post-test counselling and will collect blood samples from consenting participants at the survey site. Rapid testing will be conducted using a serial testing scheme based on the national algorithm for approved test kits. The kits will col...
Despite progress in antiretroviral therapy, pre-exposure prophylaxis, microbicides, and other preventive strategies, a vaccine to prevent HIV-1 infection remains desperately needed. Development of an effective vaccine is challenged by several immunologic
Table 1 Distribution of the six major subtypes in the Newdb dataset. Full size table Table 2 Distribution of tropisms in the different datasets. Full size table Machine learning method: XGBpred Extreme gradient boosting (XGboost), like RFs used by T-CUP225, is an ensemble algorithm of decisio...
To evade host immune defences, human immunodeficiency viruses 1 and 2 (HIV-1 and HIV-2) have evolved auxiliary proteins that target cell restriction factors. Viral protein X (Vpx) from the HIV-2/SIVsmm lineage enhances viral infection by antagonizing SAMHD1 (refs12), but this antagonism is ...