This graphic shows the HIV testing algorithm as recommended in 2014 and 2018 by the Centers for Disease Control and Prevention (CDC) and Association of Public Health Laboratories (APHL). The stages of HIV infection and the tests that are recommended are [5,30]. ...
Performance measures did not differ substantially with regards to which machine learning algorithm was used. When we calibrated the models to a specificity of 99·9% (pre-exposure prophylaxis (PrEP) scenario), we found a posit...
1. HIV-1 DNA定性检测:HIV-1 DNA定性检测采用PCR方法扩增HIV-1基因组的保守区,从而测定外周血单个核细胞中HIV-1前病毒的DNA,目前被广泛用作诊断婴儿HIV感染标准方法,也是通常作为研究中与其他检测方法比对的方法[6]。由于抗逆转录病毒疗法不能治愈HIV感染,且HIV前病毒DNA是整合在细胞基因组中,因此,HIV-1 DNA会...
et al. Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm. J. Virol. 83, 7337–7348 (2009). Article CAS PubMed PubMed Central Google...
D. Automated phylogenetic detection of recombination using a genetic algorithm. Mol. Biol. Evol. 23, 1891–1901 (2006). Article PubMed Google Scholar Guindon, S. et al. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst. Biol....
immunologic correlates of protection to improve development of future HIV-1 pox-protein and other vaccine strategies. Trials in Thailand and South Africa have built upon the RV144 framework to provide additional immunologic insights which enable current and future efficacy testing of related vaccine ...
> 100 cells/mm3,n = 9); and (E) the healthy control, untreated TB-positive and untreated HIV/TB co-infected samples after the exclusion of the seven samples (n = 53). The distance measure used in these dendrograms was Pearson’s and the clustering algorithm, Ward’s D...
Performance of the Alere Determine (TM) HIV-1/2 Ag/Ab Combo Rapid Test with algorithm-defined acute HIV-1 infection specimens Background: The capacity of HIV Antigen/Antibody (Ag/Ab) immunoassays (IA) to detect HIV-1 p24 antigen has resulted in improved detection of HIV-1 infectio... Pa...
Interest in HIV self-testing—an approach to increase access to HIV testing—has increased since 2014.1 As a discreet and convenient approach, HIV self-testing might be most useful in reaching people who are reluctant or unable to access existing HIV testing services because of concerns about pr...
The CDRs had been aggregated using an algorithm that accounts for the time spent by each individual in each constituency. In the OD matrix, rows specify the constituencies where individuals live, columns specify the constituencies they visit, and the entries/coefficients in the matrix specify ...