Gene counts were determined using HTSeq.35. Testing for differential gene expression and cerebral blood flow and gene-expression correlation was done using DESeq. 236. Genes were counted as differ- entially expressed where they had a moderated fold change of 2 or more, contrasting coil to ...
We studiedAPOEε2, ε3 and ε4 genotype and 2 clusters of genes: 1) APP-Aβ metabolism genes: 31 genes involved in Aβ production (APP,PSEN1,PSEN2,ADAM9,ADAM10,ADAM17,BACE1,BACE2,NCSTN,PSENEN,APH1B, MEP1B, GPR3), APP stabilization (APLP1,APBA1), APP recycling (SORL1), Aβ depo...
To this end, we generated a tiling array library that contained all pos- sible sgRNAs targeting seven selected genes. The selected genes included two essential genes (RPL8 and RPL15), two dispensable genes (CCR5 and CD4), and three genes that were expected to give an intermediate phenotype ...
Gene counts were determined using HTSeq.35. Testing for differential gene expression and cerebral blood flow and gene-expression correlation was done using DESeq. 236. Genes were counted as differ- entially expressed where they had a moderated fold change of 2 or more, contrasting coil to ...