In summary, we generated a dataset with unprecedented power to study the signs of selection and drug-resistance mechanisms in major Candida pathogens. Structural variants underlie intraspecific variation To determine the relevance of considering different variant types in subsequent analyses, we quantified ...
Gene Tierney. Actress: Laura. With prominent cheekbones, luminous skin and the most crystalline green eyes of her day, Gene Tierney's striking good looks helped propel her to stardom. Her best known role is the enigmatic murder victim in Laura (1944). Sh
To address these gaps, we used approximately 2,000 available genomes from majorCandidaspecies to investigate two open questions in clinical adaptation. First, we used phylogenetics andπN/πS-inspired tools to infer the genes with signatures of recent and potentially clinically relevant selection inC....
gene expression in Jojoba Bader Alsubaie1,2, Ardashir Kharabian‑Masouleh1, Agnelo Furtado1, Othman Al‑Dossary1,2, Ibrahim Al‑Mssallem2 and Robert J. Henry1,3* Abstract Background Dioecious plants have male and female flowers on separate ...
Using DAVID, we mapped gene-level functional annotations (GO) and signaling pathway information (KEGG) to individual genes (see Additional file 1: Table S5). Next, we performed an enrichment analysis for each disease or gene ontology/pathway in a pan-cancer study as follows: $$glm\ (N \...
Worldwide wheat production is under constant threat by fast-evolving fungal pathogens. In the last decades, wheat breeding for disease resistance heavily relied on the introgression of chromosomal segments from related species as genetic sources of new r
The analysis of gene sets is usually carried out based on gene ontology terms and known biological pathways. These approaches may not establish any formal relation between genotype and trait specific phenotype. In plant biology and breeding, analysis of gene sets with trait specific Quantitative Trait...
Music ("Lonesome Polecat"), Acknowledgement (the special style and content of the musical sequences were created by) (as Gene De Paul) $5MM $5MM The Place Between Our Bodies (1975) (Short) - Writer ("You Don't Know What Love Is") (uncredited) The Great McGonagall (1975) ...
A wide array of tools belongs to this category, including simple ones, such as GOstat [2] and DAVID [3] or more sophisticated like RuleGO [4]. The main statistical assessment of a gene set significance in ORA is based on hypergeometric, χ 2 or Fisher exact test, which makes first ...
Sex pheromone communication in moths has attracted the attention of evolutionary biologists due to the vast array of pheromone compounds used, addressing questions of how this diversity arose and how male reception has evolved in step with the female signal. Here we examine the role of changing ge...