Fig. 3.dCas9-p300 chimeric protein enhances acetylation of H3K27 (histone H3 lysine 27) in the promoter region to increase gene expression. View article Review article Molecular regulation of cardiac hypertrophy The International Journal of Biochemistry & Cell Biology ...
Histonesare the main protein component of chromatin and they can be divided into two major groups: corehistonesand linker histones. Core histones: H2A, H2B, H3, and H4 have a rather simple structural organization in which a central folded domain, thehistonefold[1], is flanked by two disordere...
Emerging evidence has revealed that PKM2 has oncogenic functions independent of its canonical pyruvate kinase activity, serving as a protein kinase that regulates gene expression. However, the mechanism by which PKM2, as a histone kinase, regulates the transcription of genes involved in triple-negative...
The Novo Nordisk Foundation Center for Protein Research is supported financially by the Novo Nordisk Foundation (grant agreement: NNF14CC0001). Reviewer information Nature Reviews Molecular Cell Biology thanks M. Hirschey, Y. Zhao and the other anonymous reviewer(s) for their contribution to the ...
Lysine acetylation is a widespread and versatile protein post-translational modification. Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal, respectively, of acetyl groups at both histone and non-histone targets. In this
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Dynamic regulation of effector protein binding to histone modifications: the biology of HP1 switching. Cell Cycle. 2006; 5 :2842–51. doi: 10.4161/cc.5.24.3540. [ Cross Ref ]Dormann HL, Tseng BS, Allis CD, Funabiki H, Fischle W. Dynamic regulation of effector protein binding to ...
In subject area: Biochemistry, Genetics and Molecular Biology Histone methylation and demethylation involve modification of certain amino acids in a histone protein by strategic addition or removal of one, two, or three methyl groups thus turning the genes in DNA “off” and “on”, respectively....
The present invention provides a human histone-like protein (HLP) and polynucleotides which identify and encode HLP. In addition, the invention provides expression vectors and host cells, agonists, an
ac—acetyl group; ADA2b—adapter protein; AGL15—AGAMOUS-LIKE 15; ARF—AUXIN RESPONSE FACTOR; Aux/IAA—Auxin/INDOLE-3-ACETIC ACID; AuxRE—Auxin RESPONSE ELEMENT; BBM—BABY BOOM; bZIP—bZIP-RELATED BASIC LEUCINE ZIPPER; FUS3—FUSCA3; GRE—G-BOX RELATED ELEMENT; HAG1/GCN5—HISTONE ...