Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma. Int J Cancer. 2015; 136:289-298.Chiba T, Saito T, Yuki K, Zen Y, Koide S, Kanogawa N, Motoyama T, Ogasawara S, Suzuki E, Ooka Y, Tawada A, Otsuka M, Miyazaki M, Iwama ...
The histone methyltransferase KMT1A / SUV39H1 is the mammalian homologue of the Drosophila PEV modifier Su(var)3-9 protein. SUV39H1 contains the SET and chromo domains. In eukaryotic cells,SUV39H1 and the methyl-lysine binding protein HP1 interact to
Suv39h1 is a histone H3 lysine-9 (H3-K9) specific methyltransferase (HMT) that is associated with gene silencing through chromatin modification. The transition from proliferation into differentiation of muscle cell is accompanied by transcriptional activation of previously silent muscle genes. I report...
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Post-translational modifications of histones H3 and H4 associated with the histone methyltransferases Suv39h1 and G9aHumansHela CellsMethyltransferasesHistone-Lysine N-MethyltransferaseRepressor ProteinsHistonesHistocompatibility AntigensChromatin ImmunoprecipitationHistone Code...
产品名称: Histone Methyltransferase (SUV39H1) Blocking Peptide .0 订购此产品 供应商: Biovision 规格: 50 μg 目录价: 1425 库存状态: 3周到货 CAS编号: 应用范围: 生化实验 种属来源: 相关信息: Histone Methyltransferase (SUV39H1) Blocking Peptide Product Name: Histone Methyltransferase (SUV39H1...
Histone-Lysine N-MethyltransferaseLysineMethylation of histone H3 at lysine 9 (H3-K9) mediates heterochromatin formation by forming a binding site for HP1 and also participates in silencing gene expression at euchromatic sites. ESET, G9a, SUV39-h1, SUV39-h2, and Eu-HMTase are histone ...
SUV39H1, the first identified histone lysine methyltransferase in human, is involved in chromatin modification and gene regulation. SUV39H1 contains a chromodomain in its N-terminus, which potentially plays a role in methyl-lysine recognition and SUV39H1 targeting. In this study, the structure of...
Although histone methylation and its involvement in transcription were first reported in the 1960s,6it was only about 15 years ago that the first histone methyltransferase, SUV39H1, containing a catalytic SET (Su(var)3–9, Enhancer of Zeste, and Trithorax) domain, was identified,7igniting disco...
Mammalian cells express dozens of H3K9 methyltransferases containing catalytic SET domains flanked by pre-SET and post-SET domains; these include su(var)3-9 homolog 1 (SUV39H1)/KMT1A, SUV39H2/KMT1B, SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)/KMT1E, G9a/euchromatic his...