HMTs分为两类:赖氨酸甲基转移酶(Histone lysine methyltransferase,HKMTs)和精氨酸甲基转移酶(Protein arginine methyltrans ferases,PRMTs)(图6)(Liu et al., 2010)。 图6 赖氨酸或精氨酸残基上的组蛋白甲基化和去甲基化是一个复杂的、动态的表观遗传标记调控系统(Liu et al., 2010)。(a)一甲基化、二甲...
Thus, we assumed that the PHD finger of SIZ1 interacts with ATX to block activity of histone lysine methyltransferase. ATX1–5 proteins contain catalytic SET domains, which bind S-adenosylmethionine and the substrate lysine43. The SET domains of ATX proteins fused with maltose-binding protein (...
HATs, also called lysine acetyltransferases or KATs, use acetyl CoA as a cofactor to add an acetyl group to the ε-amino group of lysine, and neutralize the positive charge on lysine, reduce the connection between histones and DNA, resulting in transcriptional activation of genes [42]. These ...
each exhibiting distinct functional attributes divergent from those of lysine ac.7Research has pinpointed 63 instances of histone hib marks, a number that eclipses the identified histone lysine ac sites. Unlike the predominantly N-terminal tail localization of known cr and ac modifications, hib mark...
Drosophila Su(var)3-9 protein was the first identified histone lysine methyltransferase specific for H3K9 (Rea et al.2000). Multiple Su(var)3-9 methyltransferases have been identified in mammals and are shown to play an important role in chromatin function and development (Sims et al.2003). ...
[14,15,16]. The majority of histone methylations are located on the histone tails which are intrinsically disordered and serve as signaling antennas of chromatin [14]. Histone methyltransferase (HMT) catalyzes the methylation of lysine and arginine residues of histones by using S-adenosyl ...
Using chromatin immunoprecipitation and deep sequencing (ChIP-Seq) we established the whole-genome distribution patterns of histone H3 lysine 4 mono-, di-, and tri-methylation (H3K4me1, H3K4me2, and H3K4me3, respectively) in Arabidopsis thaliana during watered and dehydration stress conditions. In ...
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase Nature, 416 (2002), pp. 556-560 View in ScopusGoogle Scholar Jenuwein, 2006 T. Jenuwein The epigenetic magic of histone lysine methylation FEBS J., 273 (2006), pp. 3121-3135 CrossrefView in ScopusGoogle Scholar ...
Here, we show that in Arabidopsis thaliana, the evolutionarily conserved nuclear mRNA cap-binding complex (CBC) forms multi-protein complexes with a conserved histone 3 lysine 4 (H3K4) methyltransferase complex called COMPASS-like and a histone 3 lysine 36 (H3K36) methyltransferase to integrate ...
Histone acetylation is controlled by histone acetyltransferases and histone deacetylases (HDACs),2 which add or remove acetyl groups to lysine side chains, respectively. The addition of acetyl groups to histones relaxes chromatin and promotes the recruitment of transcriptional cofactors, whereas HDACs ...