Chieh YangUniversity of California, Riverside, San Bernardino, CALinnea BurkeLoma Linda University Health System, Department of Surgery, Loma Linda, CAYanghee WooCity of Hope National Cancer Center, Duarte, CAAmerican Society of Clinical OncologyJournal of Clinical Oncology...
HIPEC delivers chemotherapy directly to cancer cells in the abdomen. This allows for higher doses of chemotherapy treatment. Heating the solution may also improve the absorption of chemotherapy drugs by tumors and destroy microscopic cancer cells that remain in the abdomen after surgery. ...
This study aimed to establish a feasible large porcine model for dynamic assessment of cisplatin concentrations in carcinomatosis-relevant abdominal tissues using microdialysis during and after HIPEC combined with cytoreductive surgery. Methods In total, eight pigs underwent open abdominal cytoreductive surgery...
Cytoreductive surgery Oxaliplatin 5-FU 1. Background Hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) represent a widely accepted therapeutic approach in oncological surgery. Severe side effects are known, but to our knowledge no other case of lethal rapid progressive pulmo...
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are effective treatments for advanced colorectal cancer with peritoneal metastases allowing median survival of up to 62 months and 5 year survival in excess of 40%.3These modalities are being employed in Ninewells Hospital ...
Objectives Cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS-HIPEC) for peritoneal malignancies are complex surgeries marked with hemodynamic perturbations, temperature fluctuations, blood loss and metabolic disturbances in the in
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are effective treatments for advanced colorectal cancer with peritoneal metastases allowing median survival of up to 62 months and 5 year survival in excess of 40%.3These modalities are being employed in Ninewells Hospital ...
Among these, the surgical results of patients who underwent HIPEC through primary or interval cytoreductive surgery (ICS) were compared with those who underwent HIPEC after recurrence. Results: Recurrence occurred in 76.5% of patients who underwent HIPEC and the average opera...
When primary complete surgery is not possible, neoadjuvant chemotherapy (NACT) is provided; however, the peritoneum-plasma barrier hinders the drug effect. The intraperitoneal administration of chemotherapy could eliminate residual microscopic peritoneal tumor cells and increase this effect by hyperthermia. ...