Joshi, A.S. (1994) Plasma protein binding of highly bound drug: implications of radiochemical impurities. J. Pharm. Sci. 83, 1187-1188.Joshi, A.. Pieniaszck. H., Quon. C. and King, S. (1904) Plasma protein binding of highly bound drugs: implications of radi~hemical im- purities....
BACKGROUND: Although various drugs used by anesthesiologists highly bind to plasma proteins, the impact of iatrogenically induced hypoproteinemia on their pharmacologic effects has never been investigated. The authors determined the pharmacokinetics of ceftriaxone, a cephalosporin that binds strongly to albu...
Suwon city, Republic of Korea) for detecting the histidine-rich protein 2 (HRP2) ofP. falciparumaccording to the Manufacturer’s instructions. Then, 70 µl
RESULTS Decreased COMT Enzyme Activity and Protein Abundance in COMT-Met vs Wild-Type Mice As anticipated, COMT activity and protein abundance was reduced in COMT-Met mice, compared with wild-type mice. Abundance of both the soluble (S-COMT; Figure 1a) and membrane-bound (MB-COMT; Figure 1...
thermophila-specific, meaning that they do not have identifiable known homologs in any other organism. However, all three possess clusters of glutamines in their primary sequence suggestive of a role in transcription [30]. The fifth protein SAINTexpress analysis revealed to co-purify with Snf5Tt-...
Protein delivery Quartz crystal microbalance 1. Introduction There has been a shift in medical modality from low-molecular-weight medicines that are chemically synthesized to high-molecular-weight medicines such as proteins andnucleic acids. For the delivery of such proteins, research to date has mainl...
The dialyzed cell supernatant was applied to Nickel-NTA agarose beads (Qiagen, Hilden, Germany) using a gravity-flow column (BioRad, Hercules, CA, USA), washed with 20 column volumes of IMAC wash buffer (20 mM Tris, 500 mM NaCl, 30 mM Imidazole, pH 8.0) and the bound protein was ...
Although not completely devoid of risk, pregnancy can be managed in virtually all patients affected by even the most complex forms of congenital heart disease. It is not however advisable in patients with any form of pulmonary arterial hypertension. Preg
A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, breast, pancreas, colon, lymphoc...
These drugs are highly protein bound and poorly dialyzable; however, it has been suggested that albumin-supplemented dialysate may enhance dialytic clearance. We investigated whether the addition of albumin to dialysate affects dialytic clearance of VPA, CBZ and PHT.Mariann D. Churchwell1,2, ...