High-grade gliomas (HGG), including anaplastic astrocytoma and glioblastoma, are diffusely infiltrating, malignant tumors of the central nervous system. HGG may arise at any age and, with rare exceptions, are uniformly fatal despite aggressive multimodal therapies including surgery, radiation therapy, ...
High-grade gliomas (HGG) represent a challenging subset of brain tumors characterized by aggressive nature and poor prognosis. Histopathology remains to be the standard for diagnosis, however, it is invasive, prone to sampling errors, and may not capture the full tumor heterogeneity and evolution ov...
In the past 10 years, little progress has been made in the treatment of HGG [3]. The identification of several biomarkers is promising for predicting the prognoses of glioma patients [4,5]. However, based on current treatment methods, the prognostic prediction of high-grade gliomas remains fru...
KeywordsHigh-gradeglioma,glioblastomamultiforme,surgery,radiotherapy,chemotherapy,health-related qualityoflife .cjcsysuChineseAnti-CancerAssociationCACA1 Amongmorethan100differenthistologicalsubgroupsofbrain tumors,high-gradegliomas(HGG)arethemostfrequententities, ...
We found that nimotuzumab with or without radiotherapy, chemotherapy in newly diagnosed or recurrent HGG, such as glioblastoma multiforme (GBM), anaplastic astrocytomas (AA), and diffuse intrinsic pontine glioma (DIPG), might improve the response rate or the survival time. In conclusion, nimotuzumab...
Patients with high-grade glioma (HGG) face debilitating symptoms and a poor prognosis. The aims of this study were to better understand how patients with HGG experience life with a brain tumor, and to explore their professional care needs. We conducted a qualitative research of HGG patients' ex...
Neutrophils-to-lymphocytes ratio (NLR) in blood correlates with glioma grade and is highest in GBM. Moreover, an elevated NLR is associated with poor clinical outcomes in GBM patients [8,9]. HGG TME is characterized by low numbers of CD8+ cytotoxic infiltrating T cells (TIL). Conversely, ...
High grade gliomaH3.3 G34SurvivalH3F3A G34 (H3.3 G34)-mutant high-grade gliomas (HGG) are rare, and newly recognized infiltrating gliomas of the cerebral hemisphere. Here, we report the clinicopathological and molecular characteristics of four H3.3 G34-mutant gliomas in terms of its ...
Summary Patients with high-grade glioma (HGG) can be classified as having a favourable prognosis (younger or with good performance status) or a poor prognosis (older or with poor performance status) with median survival of 12–24 months and 6–9 months, respectively. The standard management for...
High-grade glioma (HGG) is an aggressive brain tumor with poor survival rates. Predicting survival outcomes is critical for personalized treatment planning. In recent years, artificial intelligence (AI), particularly machine learning (ML) and deep learning (DL) models, has emerged as a promising ...