screeningBackground The Ontario Breast Screening Program was expanded in 2011 to offer annual MRI and mammography to women with high‐risk genetic mutations (e.g., BRCA1/2) and women with strong family histories and ≥25% estimated lifetime risk of breast cancer. Data to support high‐risk ...
Population-based mammography screening programs primarily aim at postmenopausal women, where the incidence of breast cancer in normal-risk women is highest. These programs are not adequate for high-risk women such as BRCA1 or BRCA2 mutation carriers, in whom breast cancer not only occurs much more...
OBJECTIVE: In July 2011, the provincial government of Ontario, Canada, approved funding for the addition of annual breast MRI to mammography screening for all women 30-69 years old considered to be at high risk for breast cancer. The purpose of this study was to evaluate the diagnostic perform...
Advances in counseling and surveillance of patients at risk for pancreatic cancer. Gut 2007;56:1460–1469 Article PubMed Google Scholar Eppel A, Cotterchio M, Gallinger S. Allergies are associated with reduced pancreas cancer risk: A population-based case–control study in Ontario, Canada. Int...
With these terms in the model, none of the other predictors that had survived the domain-wise screening procedure (Table 3) were related to conversion risk, indicating that their predictive associations were redundant with the other model terms. In particular, treatment with antipsychotic drugs ...
Most babies are born healthy and grow and develop normally through childhood. There are, however, clearly identifiable high-risk groups of survivors, such as those born preterm or with ill-health, who are destined to have higher than expected rates of he
(LD;r2 = 1.0) with rs116446171. Although other SNPs appeared to be strongly associated with risk, conditional association analyses suggest a single signal accounted for the association in this region (Supplementary Table3). SNPs at chromosome 14q32.13 also reached genome-wide significance, ...
Patients at higher than average risk of heritable cancer may process risk information differently than the general population. However, little is known about clinical, demographic, or psychosocial predictors that may impact risk perception in these group
From a societal angle, an expansion of HIV screening and treatment is cost-effective: A combination of those approaches in the US could prevent 17% of infections and cost USD 21,580/QALY gained, even though changes in risk behaviour are also necessary to reduce the HIV epidemic significantly ...
The proton beams provide potential cost-efficiency, exclusively, for pediatric brain neoplasms59, selectively identified breast carcinomas with elevated cardiotoxicity risk60, locoregionally advanced non-small cell lung cancer (NSCLC)61,62, and high-risk head and neck malignancies63. It is worth ...