CD14PrognosisNivolumabPembrolizumabIncrease in pretreatment expression levels of PD-L1 on CD14 + monocytes is associated with the OS of patients treated with immune checkpoint inhibitors. Further evaluation of large sample size and each specific cancer type might clarify the predictive role of PBMC in ...
PHF19 in hematopoiesis PHF19 balance quiescence and differentiation of hematopoietic stem cells (HSCs)In human hematopoiesis, PHF19S expression is higher in stem/progenitor cells and relatively decreases during differentiation (except in monocytes); however, PHF19L ...
Another study found a significant increase of CD14+ monocytes in blood and in tumors of patients with IBC compared to non-IBC38, consistent with our findings. Taken together, our data reveal that the prominent presence of macrophages in close contact with tumor cells is a common characteristic o...
147 blood samples and 43 paired tumor specimens from 43 patients with mPDAC were sequenced. The most common driver genes with high MAF wereKRAS(tumor, 35%; ctDNA, 37%) andTP53(tumor, 37%; ctDNA, 33%). Mutation rates of KRAS and TP53 in ctDNA were significantly higher in patients wit...
Circulating monocytes were isolated using a mouse monocyte isolation kit. Whole blood was lysed on ice for 15 min, and resuspended in PBS containing 2% fetal bovine serum. Selection cocktail was pre-mixed for 5 min, followed by adding to the cell suspension and incubating for 5 min at 4 °...
High salt is positively associated with the risk of many diseases. However, little is known about the mechanisms. Here we showed that high salt increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human and mouse macrophages. High salt also potentiat...
Chiu KM, McPherson LH, Harris JE, Braun DP (1984) The separation of cytotoxic human peripheral blood monocytes into high and low phagocytic subsets by centrifugal elutriation. J Leuk Biol 36:729–737Chiu KM, McPherson LH, Hams JE, Braun DP. The separation of cytotoxic human peripheral blood ...
Epithelial ovarian carcinoma (EOC) is the predominantly lethal gynecological cancer and ranks seventh among the most commonly diagnosed cancer in women worldwide [1]. High-grade serous ovarian cancer (HGSC) is the most common EOC and accounts for as many as 60% of EOC cases. Ovarian clear cel...
By analyzing 333 individual DCs and monocytes from metastatic melanoma, Nirschl et al. revealed that homeostatic modules were enriched in monocytes and DCs and were positively correlated with IFN-γ signatures.175Moreover, SOCS2, a member of the SOCS family that uniquely degrade all other members,...
This suggests that monocytes, as implied by other studies, could become important targets in both understanding COVID-19 disease progression as well as improving recovery at the early phase of ICU admission [37]. Fig. 3 Overview of cell population abundances in peripheral blood profiles. a ...