Peripheral blood monocytes express the high-affinity receptor, FceRI (abstract). J Invest Dermatol 1993;101:425.Turner H, Kinet J-P (1999) Signalling through the high-affinity IgE receptor FCεRI. Nature 402: B24–B30Turner, H. and Kinet, J.P. (1999) Signalling through the high-...
In this work, a simple, inexpensive and reproducible technique of flotation density gradient centrifugation was developed to isolate monocytes with high purity and yield from peripheral blood mononuclear cells (PBMC) using Histopaque solution, density and osmolarity of which were modified to 1.072 g/...
73,74Single-cell sequencing has revealed that AML cells are diverse, arising from the proliferation and accumulation of immature cells in bone marrow development. Mature blood cells (lymphocytes, erythrocytes, and megakaryocytes) are derived from normal hematopoietic stem cells. Results of single...
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting more than 2.8 million people worldwide [1,2]. The major pathological hallmarks of MS are blood–brain barrier (BBB) breakdown, immune cell infiltration, demyelination, axonal injury, and neuron...
(h) Flow cytometric analysis of cells in aorta walls shows that [S]-rHDL is taken up by plaque macrophages; furthermore, macrophages are targeted more efficiently than monocytes (N ¼ 3 per time point). 4 NATURE COMMUNICATIONS | 5:3065 | DOI: 10.1038/ncomms4065 | www.nature.com/...
suggesting that these cells kill autologous tumor cells. Chen et al. found that monocytes were enriched in the M2 state of the bladder tumor region; moreover, a cluster of DCs with high LAMP3 expression was correlated with Treg recruitment, indicating the regulation of immunosuppressive formation....
However, the results of scRNA-seq analysis with OCCC samples have not been reported to date. Cell cycle phase and SCENIC analyses in this study partially explained the chemoresistance mechanism underlying OCCC oncogenesis. Recent studies discovered that cisplatin caused cell death mainly by preventing ...
single-cell transcriptomes from 153,554 cells from 18 COVID-19 and 13 control PBMC samples, annotated by cell types. Dashed box shows the two clusters of classical monocytes, HLADRhi (#7) and S100Ahi/HLADRlo (#1). f Comparison of differential cell counts (as % of all PBMCs) between ...
(2012). CD16+ monocytes control T-cell subset development in immune thrombocytopenia. Blood 120, 3326–3335. Article CAS PubMed PubMed Central Google Scholar Zhou, Z.H., Zhuang, L., Li, X.Y., Li, J., and Luo, S.K. (2010). The role of B cell-activating factor secreted by ...
Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic megakaryocytes (LCM) are critical negative regulators of HSC and critical for plate