高迁移率族蛋白B1(high mobility group box 1 protein, HMGB 1)是巨噬细胞释放出一种核蛋白。HMGB家族有3个成员,即HMGB1、HMGB2和HMGB3,三者在氨基酸序列上有80%的一致性。HMGB1是含量最丰富的HMG蛋白,在典型的哺乳动物细胞内约有106个分子,平均10~15个核小体即可含有1个HMGB1分子。HMGB1广泛分布于淋巴组织、...
High Mobility Group Proteins 14 and 17 Can Prevent the Close Packing of Nucleosomes by Increasing the Strength of Protein Contacts in the Linker DNA - A study shows that digestion of HMG containing chromatin with micrococcal nuclease produces DNA fragments that were approximately 10 and 20 base pa...
A large number of transcription factors contain HMG-like domains. The specificity of these proteins varies but a common feature is that they distort the DNA structure and have an affinity for distorted DNA structures. The change in DNA electrophoretic mobility is correlated with this altered ...
高迁移蛋白(high-mobility group,HMG)相关知识点: 试题来源: 解析 活性染色质含有的两种高丰度的小分子非组蛋白,HMG14和HMG17。它们携带异常高的电荷,含有25%的碱性氨基酸和30%的酸性氨基酸,因其相对分子质量小(30 kD),在凝胶电泳中移动较快,故称为HMG蛋白。 暂无解析...
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High mobility group box 1 (HMGB1) regulates autophagy in response to oxidative stress. Exogenous hydrogen peroxide (H(2)O(2)) treatment or knockdown of the major superoxide scavenger enzyme, superoxide dismutase 1 (SOD1), by small interfering RNA (siRNA) increases autophagy in mouse and human...
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The High Mobility Group A1 ( HMGA1 ) chromatin regulator gene is induced by growth factors and highly expressed during embryogenesis and in HSCs, but silenced in differentiated tissues (Resar et al, Cancer Res 2018). In acute leukemia, myeloproliferative neoplasms, and solid tumors, HMGA1 ...
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The non-histone chromatin binding protein High Mobility Group AT-hook protein 2 (HMGA2) plays important roles in the repair and protection of genomic DNA in embryonic stem cells and cancer cells. Here we show that HMGA2 localizes to mammalian telomeres and enhances telomere stability in cancer ...