Borderline high serum free light chain kappa/lambda ratios are seen not only in dialysis patients but also in non-dialysis-dependent renal impairment and inflammatory states. Am J Clin Pathol 2009;132:309.Marshall G, Tate J and Mollee P. Borderline high serum free light chain k/ ratios are...
Elevated Serum Free Light Chains Are Associated With Event-Free and Overall Survival in Two Independent Cohorts of Patients With Diffuse Large B-Cell Lymphoma The serum free light chain (FLC) assay quantitates free kappa (κ) and free lambda (λ) immunoglobulin light chains. This assay has prog...
Kappa-RBD produced by glycoengineered Pichia pastoris elicited high neutralizing antibody titers against pseudoviruses of SARS-CoV-2 variants [624]. U50,488 H, induced autophagy in Neuro-2A cells stably expressing the human KOR by upregulating microtubule-associated protein Light Chain 3-II (LC3-II...
According to the composition of deposits, three categories are distinguished: light-chain deposition disease (LCDD), heavy-chain deposition disease (HCDD), and light- and heavy-chain deposition disease (LHCDD).1., 2., 3., 4., 5., 6. Kappa light chains (LCs) are involved in about two...
For example, conversion of Phe90 in the murine kappa light chain variable domain germline sequence IgkV9-124*01 to TyrL91 in 10G4 provided a hydrogen bond donor that stabilized a water-mediated contact to the C5-OH of the LTC4 arachidonic acid moiety, while mutation in the IgHV3-1*02 ...
tssViuunLlbgtgsi1nee4qngueppseaa,nii4rrtsl8eydwrseeVesrquHeul/ctVeelnodLcngieeneddnrveieniscatofooSvarhenrerygeapveorylficsaVeanqtHdeugsleieengnqhceuitnsecgnoh.cnaOeliysnf,, mammalian expression plasmids containing human IgG1 constant regions and kappa light chain regions for chimeric ...
The G‐Protein‐coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light‐chain enhancer of activated B cells (NF‐κB) in mice Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in...
In a preferred embodiment, antigen is administered directly to mice which comprise DNA loci encoding both human Ig heavy chain variable region and kappa light chain variable region (Veloclmmune®), with an adjuvant to stimulate the immune response. Such an adjuvant includes complete and incomplete...
In general, that response involves the following steps: first, toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) to initiate the antiviral innate immune response [152,153]; next, the nuclear factor kappa light chain enhancer of activated B cells (NF-κB) and ...
It is evident that under these conditions the normalisation of the melatonin level is not sufficient to correct metabolic disorder, which can be achieved by suppressing the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) or by inducing the nuclear-factor-E2-related factor...