Borderline high serum free light chain k/ ratios are seen not only in dialysis patients but also in non-dialysis-dependent renal impairment and inflammatory states. Am J Clin Pathol 2009; 132: 309.Marshall G, Tate J, Mollee P. Borderline high serum free light chain kappa/lambda ratios are...
Borderline High Serum Free Light Chain κ/λ Ratios Are Seen Not Only in Dialysis Patients but Also in Non–Dialysis-Dependent Renal Impairment and Inflamm... Borderline high serum free light chain k/ ratios are seen not only in dialysis patients but also in non-dialysis-dependent renal ...
Online high-efficiency haemodiafiltration achieves higher serum free light chain removal than high-flux haemodialysis in multiple myeloma patients:Preliminary quantitative study. Granger Vallee A,Chenine L,Leray-Moragues H,et al. Nephrology Dialysis Transplantation . 2011...
Serum free light chain (FLC) concentration and ratio were obtained as part of the diagnostic testing after this assay became available in 2003. Eligibility criteria for HDM/SCT were age >18 years, Southwest Oncology Group performance status ≤2, left ventricular ejection fraction >40%, O2 ...
dexamethasone; HCDD, heavy-chain deposition disease; HDM/ASCT, high-dose melphalan followed by autologous stem cell transplantation; LCDD, light-chain deposition disease; LHCDD, light- and heavy-chain deposition disease; MGRS, monoclonal gammopathy of renal significance; FLC, serum-free light chains...
For example, conversion of Phe90 in the murine kappa light chain variable domain germline sequence IgkV9-124*01 to TyrL91 in 10G4 provided a hydrogen bond donor that stabilized a water-mediated contact to the C5-OH of the LTC4 arachidonic acid moiety, while mutation in the IgHV3-1*02 ...
(AGE) formation, protein kinase C (PKC) activation, hexosamine pathway activation, poly(adenosine diphosphate ribose) polymerase (PARP) activation, increased oxidative stress and reactive oxygen species (ROS) production, and nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) ...
Kappa-RBD produced by glycoengineered Pichia pastoris elicited high neutralizing antibody titers against pseudoviruses of SARS-CoV-2 variants [624]. U50,488 H, induced autophagy in Neuro-2A cells stably expressing the human KOR by upregulating microtubule-associated protein Light Chain 3-II (LC3-II...
In general, that response involves the following steps: first, toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) to initiate the antiviral innate immune response [152,153]; next, the nuclear factor kappa light chain enhancer of activated B cells (NF-κB) and ...
It is evident that under these conditions the normalisation of the melatonin level is not sufficient to correct metabolic disorder, which can be achieved by suppressing the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) or by inducing the nuclear-factor-E2-related factor...