The objective of this study was to compare the effectiveness of moderate-intensity statin and ezetimibe combination therapy with high-intensity statin monotherapy. We conducted a nationwide, population-based, retrospective, cohort study of patients with ACS from 2013 to 2019. The...
1 This estimate was based largely on trials of moderate-intensity statin therapy. However, high-intensity atorvastatin (80 mg) has been shown to reduce CVD events more than moderate-intensity statins (atorvastatin [10 mg], pravastatin [40 mg], or simvastatin [20-40 mg]) in individuals with ...
(3) those who were prescribed statin less than 80% of days (24 days) in the first month after the index PCI, (4) those who were prescribed only moderate- or low-intensity statin or other combinations of statins and ezetimibe, (5) those whose statin intensity or combination had changed ...
Moderate-intensity statin with ezetimibe combination therapy was confirmed to be effective on low-density lipoprotein cholesterol (LDL-C) reduction in patients at very high risk of atherosclerotic cardiovascular disease. The research team found out that the therapy has a higher compliance rate for conti...
Down-titrating to low/moderate-intensity statins with high adherence: low/moderate-intensity statin prescription fill during the 6 months after discharge without subsequent high-intensity statin prescription fills, proportion of days covered of at least 80% from the first low/moderate-intensity statin ...
Statin intensity High-intensity 1335 (30.2) 356 (26.7) 501 (37.7) 265 (29.9) 213 (24.6) <0.001 0.115 Moderate-to-high intensity 2984 (67.6) 948 (71.1) 810 (61.0) 599 (67.6) 627 (72.5) <0.001 0.262 Low-intensity 91 (2.0) 29 (2.1) 16 (1.2) 22 (2.4) 24 (2.7) 0.049 0.159 Sta...
Individuals who reported no vigorous-intensity activities and engaged in moderate-intensity activities fewer than four times per month were classified as “sedentary”. 2.5 Statistical Analysis To assess the independent effects of each lipid measure, the study participants were categorized into seven ...
The recently published 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol management guidelines focus on intensity of statin treatment and recommend either high- or moderate-intensity statin therapy depending on cardiovascular risk [6]. High-intensity statin therapy (...
For statin-naive patients, moderate-intensity statin therapy was initiated. For those who were already taking a statin, an equivalent intensity was maintained when the LDL-C level at randomization was below 70 mg/dL, and the intensity was uptitrated when the LDL-C level was 70 mg/dL or...
1,4,24 The 2018 AHA/ACC Cholesterol Guideline recommends an LDL-C threshold of 70 mg/dL or greater in patients with atherosclerotic cardiovascular disease to consider adding nonstatin therapy to high-intensity statin therapy, and the European Society of Cardiology recommends an LDL-C goal of ...