High-intensity statin was based on statin type and dose. Analyses were also stratified by presence of pre-existing atherosclerotic cardiovascular disease (ASCVD), which was defined as a prior history of coronary or cerebrovascular disease.#Results:Among 103,748 patients, 64,159 (61.8%) were on ...
Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease View LargeDownload Figure 1. Recruitment, Randomization, and Follow-up in a Trial of Treat-to-Target Strategy or High-Intensity Statin Therapy for Coronary Artery Disease View LargeDownload aData regarding screening...
The magnitude of these changes in the lipid profile will depend on the type of statin and the dose used; those that are able to decrease 50% or more low-density lipoproteins levels are called "high-intensity statins". In recent decades, the evidence from large randomized clinical trials with...
Finally, they studied the effect of different doses within the high-intensity statin group. Patients treated with the maximum dose of statins were 10 percent more likely to survive than patients on submaximal doses. "This suggests to practitioners that instead of starting a patient on a low dos...
For high-intensity statin groups, evolocumab every 2 weeks reduced LDL-C from a baseline mean of 89 to 94 mg/dL to an on-treatment mean of 35 to 38 mg/dL; monthly evolocumab reduced LDL-C from a baseline mean of 89 to 94 mg/dL to an on-treatment mean of 33 to 35 mg/dL. ...
CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin Mohammed G. Maslub, Nur Aizati Athirah Daud, Mahasen A. Radwan, Abubakar Sha’aban & Arafa G. Ibrahim European Journal of Medical Research volume 29,...
(HealthDay)—High-intensity statin therapy is associated with coronary atherosclerosis regression, regardless of baseline lipoprotein or C-reactive protein (CRP) levels, according to a study published in the Nov. 15 issue of The American Journal of Cardi
recommendations to lower LDL cholesterol to 55 mg/dL or below. These goals have proven difficult for patients with hypercholesterolemia to reach through standard "triple therapy" of a high-intensity statin, a PCSK9 inhibitor, and ezetimibe, a drug that limits the absorption of cholesterol from ...
(73%). All the patients were candidates for high-intensity statin therapy. The participants were either predisposed to or already had atherosclerotic cardiovascular disease (ASCVD). Approximately two-thirds (62%) of the subjects were on low-dose aspirin as a prophylactic therapy for CVD events. ...
University of Cambridge, Cambridge, UK; 2Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, UK Background: Trial evidence supports statin use after ischemic stroke and recent American, European and British guidelines recommend high-intensity statins for this ind...