High-intensity statin was based on statin type and dose. Analyses were also stratified by presence of pre-existing atherosclerotic cardiovascular disease (ASCVD), which was defined as a prior history of coronary or cerebrovascular disease.#Results:Among 103,748 patients, 64,159 (61.8%) were on ...
This retrospective cohort study estimates the proportion of patients filling high-intensity statin prescriptions following myocardial infarction who
Therefore, statin initiation and intensity of statin dose are left to the discretion of the provider. In women of reproductive age, concerns about the potential teratogenicity of statin therapy may present a barrier to initiation of treatment. Statins continue to be considered teratogenic and are ...
The magnitude of these changes in the lipid profile will depend on the type of statin and the dose used; those that are able to decrease 50% or more low-density lipoproteins levels are called "high-intensity statins". In recent decades, the evidence from large randomized clinical trials with...
Effect of Very High-Intensity Statin Therapy on Regression of Coronary Atherosclerosis: The ASTEROID Trial Prior intravascular ultrasound (IVUS) trials have demonstrated slowing or halting of atherosclerosis progression with statin therapy but have not shown con... M Clearfield - 《Current Atherosclerosis...
Considering high dose statin use, we investigated the change in the proportion of high-intensity statin prescrip- tion over time and described patient characteristics for high-intensity and low/medium-intensity statin users. Restricting analysis to statin users who completed 2-year follow-up after ...
Levels of HDL-C were modestly increased by 5% to 10% across both the every-2-weeks and the monthly dose groups (4%-10% vs placebo at the mean of weeks 10 and 12) (eTables 3 and 6 and eFigure 2 in Supplement). Baseline PSCK9 levels were higher in the high-intensity statin ...
Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) to examine the effects of high-intensity statin therapy on IVUS-derived measures of coronary disease progression. Rosuvastatin is the most recently ...
Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006;295(13):1556-1565. doi:10.1001/jama.295.13.jpc60002ArticlePubMedGoogle ScholarCrossref 12. Kini AS, Baber U, Kovacic JC, et al. Changes in plaque lipid ...
We recently demonstrated, in a multi-center clinical trial, that statin therapy is associated with dose-dependent reduction in atheroslerotic inflammation (assessed with FDG-PET-CT). Here we conduct a post-hoc, blinded analysis of the images derived from that trial to test the hypothesis that ...