Node, "High-dose statin therapy with rosuvastatin reduces small dense LDL and MDA-LDL: The Standard versus high-dose therApy with Rosuvastatin for lipiD lowering (SARD) trial," Journal of Cardiology, vol. 67, no. 4, pp. 340-346, 2016....
Statin use was defined as the first prescription of statins on or after the index date. According to the British NICE guideline,11 high-intensity statin use was defined as atorvas- tatin ≥20 mg/day, rosuvastatin ≥10 mg/day, and simvastatin 80 mg/day, medium-intensity as atorvastatin 10...
Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) to examine the effects of high-intensity statin therapy on IVUS-derived measures of coronary disease progression. Rosuvastatin is the most recently ...
Medicare beneficiaries aged 66 to 75 years (n = 29 932) and older than 75 years (n = 27 956) hospitalized for myocardial infarction between 2007 and 2012 who filled a high-intensity statin prescription (atorvastatin, 40-80 mg, and rosuvastatin, 20-40 mg) within 30 days of...
All the patients were candidates for high-intensity statin therapy. The participants were either predisposed to or already had atherosclerotic cardiovascular disease (ASCVD). Approximately two-thirds (62%) of the subjects were on low-dose aspirin as a prophylactic therapy for CVD events. None of ...
Finally, they studied the effect of different doses within the high-intensity statin group. Patients treated with the maximum dose of statins were 10 percent more likely to survive than patients on submaximal doses. "This suggests to practitioners that instead of starting a patient on a low dos...
However, of those on high-intensity statin, 25% remained on insufficient statin dosage. Conclusion Switch to high-intensity statins and use of ezetimibe and PCSK9i was low in chronic ASCVD patients. Even though statin intake was high in high-risk patients, target levels were still not reached...
Interestingly, the risk of NOD seems to vary according to the type and dose of statins. Previous studies reported that various types of statins, including atorvastatin, rosuvastatin, and simvastatin, increased the risk of NOD [6, 8, 9]. Higher doses of statin therapy further increased the haz...
Patients were randomized to receive biweekly subcutaneous alirocumab (150 mg; n = 148) or placebo (n = 152), initiated less than 24 hours after urgent percutaneous coronary intervention of the culprit lesion, for 52 weeks in addition to high-intensity statin therapy (rosuvastatin, 20 ...
At the time of randomization to study drug, mean LDL-C levels were 109 to 127 mg/dL in the moderate-intensity statin groups (atorvastatin [10 mg], rosuvastatin [5 mg], and simvastatin [40 mg]), and 77 to 103 mg/dL in the high-intensity statin groups (atorvastatin [80 mg] and ...