Node, "High-dose statin therapy with rosuvastatin reduces small dense LDL and MDA-LDL: The Standard versus high-dose therApy with Rosuvastatin for lipiD lowering (SARD) trial," Journal of Cardiology, vol. 67, no
Statin use was defined as the first prescription of statins on or after the index date. According to the British NICE guideline,11 high-intensity statin use was defined as atorvas- tatin ≥20 mg/day, rosuvastatin ≥10 mg/day, and simvastatin 80 mg/day, medium-intensity as atorvastatin 10...
All the patients were candidates for high-intensity statin therapy. The participants were either predisposed to or already had atherosclerotic cardiovascular disease (ASCVD). Approximately two-thirds (62%) of the subjects were on low-dose aspirin as a prophylactic therapy for CVD events. None of ...
LDL-C Mean (95% CI)a High-Intensity Statin Moderate-Intensity Statin Atorvastatin (80 mg) Rosuvastatin (40 mg) Atorvastatin (10 mg) Simvastatin (40 mg) Rosuvastatin (5 mg) vs Placebo vs Ezetimibe vs Placebo vs Placebo vs Ezetimibe vs Placebo vs Placebo Every 2 wkMonthlyEvery 2 wkMonthlyEv...
Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) to examine the effects of high-intensity statin therapy on IVUS-derived measures of coronary disease progression. Rosuvastatin is the most recently ...
(80) demonstrated an inverse relationship between hsCRP levels and clinical response to statin therapy. There was a modestly greater relative benefit from rosuvastatin in those with hsCRP below the median cut point of 4.2 mg/l versus above 4.2 mg/l (RRR: 58% vs. 29%, respectively; p = ...
Some studies demonstrated that statin reduced the level of sST2 in HIV and multiple myeloma patients [45–47]. Our study has been the first to investigate the impact of high-dose atorvastatin and rosuvastatin on serum sST2 levels in STEMI patients. The level of sST2 was reduced in both ...
(73%). All the patients were candidates for high-intensity statin therapy. The participants were either predisposed to or already had atherosclerotic cardiovascular disease (ASCVD). Approximately two-thirds (62%) of the subjects were on low-dose aspirin as a prophylactic therapy for CVD events. ...
Patients were randomized to receive biweekly subcutaneous alirocumab (150 mg; n = 148) or placebo (n = 152), initiated less than 24 hours after urgent percutaneous coronary intervention of the culprit lesion, for 52 weeks in addition to high-intensity statin therapy (rosuvastatin, 20 ...
In any of the methods provided herein, the high-dose statin can be selected from the group consisting of atorvastatin, cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, and analogs thereof. In some embodiments, the high-dose statin can include a dose equiva...