While high-grade serous ovarian cancers (HGSOC) are initially sensitive to platinum-based therapy, resistance to chemotherapy remains a major challenge. Recently, the role of EZH2 in establishing a chemo-resistant state has been described in small cell lung cancer with a potential mechanism thought...
低级别浆液性卵巢癌(Low-grade serous ovarian cancer,简称LGSOC)是一种卵巢癌比较少见的亚型,癌细胞的生长速度较慢,细胞异型程度较低。相对于高级别浆液性卵巢癌(High-grade serous ovarian cancer),LGSOC的病情发展通常较缓慢,但复发风险很高,大约85%的患者会遭遇复发,而且会对化疗耐药。
High-grade serous tubo-ovarian cancer (HGSTOC) affects worldwide 239,000 women each year [1] and is typically characterised by a high recurrence rate with poor long-term survival [2,3]. HGSTOC often becomes resistant to most treatment options, a phenomenon that has been attributed to the e...
Ovarian cancer (OC), especially high-grade serous cancer (HGSC), is a highly heterogeneous malignancy with limited options for curative treatment and a high frequency of relapse. Interactions between OC and the immune system may permit immunoediting and immune escape, and current standard of care ...
High grade serous ovarian carcinoma (HGSOC) is a highly heterogeneous disease that typically presents at an advanced, metastatic state. The multi-scale complexity of HGSOC is a major obstacle to predicting response to neoadjuvant chemotherapy (NACT) and
Combination chemotherapy is an established approach used to manage toxicities while eliciting an enhanced therapeutic response. Delivery of drug combinations at specific molar ratios has been considered a means to achieve synergistic effects resulting in
Endocrine therapy is used as maintenance in estrogen receptor (ER) positive breast cancers and has been proposed in low-grade serous ovarian cancers (LGSOC). Here we examine a rationale for its use as maintenance in high-grade serous ovarian cancers (HGSOC). Methods We accessed the TCGA PAN...
Following a period of slow progress, the completion of genome sequencing and the paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led to a new perspective on the biology and therapeutic solutions for this deadly cancer. Experimental models were revisited...
The clinicopathological parameters such as residual tumor, grade, the International Federation of Gynecology and Obstetrics (FIGO) score are often used to predict the survival of ovarian cancer patients, but the 5-year survival of high grade serous ovarian cancer (HGSOC) still remains around 30%....
海外直订Tumor Microenvironment High Grade Serous Ovarian Cancer 高级别级别浆液卵巢癌的肿瘤环境科普读物 683元 (包邮,需用券)价格:783元满600减20每300减40淘金币可抵3%满1600减50满300减5满1000减30海外直订The Tumor Microenvironment of High Grade Serous Ovarian Cancer 高级别浆液性卵巢癌的肿瘤微环境20...