低级别浆液性卵巢癌(Low-grade serous ovarian cancer,简称LGSOC)是一种卵巢癌比较少见的亚型,癌细胞的生长速度较慢,细胞异型程度较低。相对于高级别浆液性卵巢癌(High-grade serous ovarian cancer),LGSOC的病情发展通常较缓慢,但复发风险很高,大约85%的患者会遭遇复发,而且会对化疗耐药。
LGSOC, low-grade serous ovarian cancer; HGSOC, high-grade serous ovarian cancer; STIC, serous tubal intraepithelial carcinoma. adapted from [3], [4], [6], [7], [18] Recently, the grading system has changed from a three level of nuclear differentiation into low-grade cancers (mild or ...
ed from Int J Gynecol Cancer 2023;0:1–14) Low-grade serous carcinoma represents less than 10% of epithelial ovarian cancers, is often diagnosed in younger women, and is associated with prolonged survival relative to high-grade serous carcinoma. In 2019, a panel of experts gathered to ...
Background: Ovarian cancer (OCa) is the deadliest of all gynecologic cancers in the United States. About 10% of all cases of serous ovarian cancer have the unusual histology named low-grade serous carcinomas (LGSOC), that has a distinct clinical behavior with a unique molecular landscape. LG...
The FDA granted an orphan drug designation to avutometinib either alone or in combination with defactinib for recurrent low-grade serous ovarian cancer.
CANCER LETTERS 581 (2024) 216528 216531 DECIPHERING THE ADAPTIVE TRAMETINIB RESISTANCE IN LOW-GRADE OVARIAN SEROUS CARCINOMA AND ITS TRANSLATIONAL POTENTIAL 来自 dx.doi.org 喜欢 0 阅读量: 5 作者:KK Wong,CW Ng,Y Tsang,DM Gershenson DOI: 10.1016/j.canlet.2023.216531 年份: 2024 ...
Low-grade serous ovarian cancer was previously thought to be a subtype of high-grade serous ovarian cancer, but it is now recognized as a distinct disease with unique clinical and molecular behaviors. The disease may arise de novo or develop from a serous borderline ovarian tumor. Although it ...
Updated findings from RAMP 201 show that avutometinib/defactinib is generally well tolerated among those with low-grade serous ovarian cancer. "These updated results confirm the potential of this new combination therapy to change practice and be the new standard for care for recurrent low-grade ...
A prospective trial of bevacizumab in combination with paclitaxel for the treatment of LGS ovarian cancer should be considered. 展开 关键词: Low-grade serous Ovarian cancer Serous borderline Low malignant potential Bevacizumab DOI: 10.1097/IGC.0000000000000190 被引量: 18 ...
Hypoxic respiratory failure in metastatic low grade serous ovarian cancer – a rare newly diagnosed patent foramen ovale Journal of Obstetrics and Gynaecology CanadaSamantha Taylor MDShuk On Annie Leung MDGabriel Levin MD