reported that high grade and non-high grade ductal carcinoma in situ (DCIS) of the breast can be subdivided into 3 cell origin subtypes (luminal, basal/stem, and null), and that high grade DCIS is more frequently associated with basal/stem cell subtypes compared to non-high grade DCIS. He...
High protein expression levels of ACSL4, ITGA2 and ITGA5 have been implicated in poor prognosis54,55,58; however, the low expression of ITGB3 in HGSOC has been associated with favorable prognosis59. Moreover, ITGA2 has been shown to impart paclitaxel resistance58, while ITGA5 from as...
Most studies, moreover, have identified the same two features, nuclear grade and necrosis, as contributing most significantly to prognosis [4鈥 6]. Nuclear grade and necrosis have been identified as independent prognostic variables in several studies [5,6]. High nuclear grade DCIS which exhibits ...
Survival Benefit of Breast Surgery for Low-Grade Ductal Carcinoma In Situ: A Population-Based Cohort Study. the clinical significance of early detection and treatment for DCIS remains unclear.To investigate the survival benefit of breast surgery for low-grade DCIS... Yasuaki,Sagara,M Anne,... -...
Patients diagnosed with DCIS, male breast cancer, or bilateral breast cancer, as well as those who underwent surgery for palliative purposes or had distant metastasis were excluded. These patients were divided into either the high-risk or low-risk group for hereditary breast cancer by the ...
The Gleason grading system represents the main tool used for predicting the prognosis and guiding the therapy of patients affected by prostate cancer36. This system, however, is blind to the genomic makeup of the cells analyzed and to spatial genetic heterogeneity across different regions of the ...
Patients diagnosed with DCIS, male breast cancer, or bilateral breast cancer, as well as those who underwent surgery for palliative purposes or had distant metastasis were excluded. These patients were divided into either the high-risk or low-risk group for hereditary breast cancer by the ...
identifiedAGR3as a tumor epithelial marker associated with DCIS ROIs, but not the invasive ROI (Fig.4).AGR3protein expression in breast tumors is significantly associated with estrogen receptor α and lower tumor grade22, suggesting thatAGR3could serve as a biomarker for prognosis and early ...
Also, appreciating the generally low malignant potential of most STICs, a new term, such as "low-grade serous tubal intraepithelial neoplasia," was suggested in place of "STIC" [81]. Like DCIS, STIC is also a noninvasive tumor of epithelial origin [45,48]. Though not invasive, these ...
Specifically, CA has been found to increase from atypical ductal hyperplasia (ADH) to ductal carcinoma in situ (DCIS), to increase with higher DCIS grade, and to be more prevalent in TNBC versus non-TNBC tumors [20,21]. CA has also been shown to be associated with chromosomal instability ...