The presence of RC in these neoplasms may signify some degree of host response to tumor and seems to be a sign of poor prognosis for some neoplasms. RC in breast cancer is vaguely defined in the older literature. We have observed periodically similar RC in a subset of high-grade ductal ...
the clinical significance of early detection and treatment for DCIS remains unclear.To investigate the survival benefit of breast surgery for low-grade DCIS... Yasuaki,Sagara,M Anne,... - 《Jama Surgery》 被引量: 34发表: 2015年 COX2 expression in high-grade breast cancer: evidence for progno...
Patients diagnosed with DCIS, male breast cancer, or bilateral breast cancer, as well as those who underwent surgery for palliative purposes or had distant metastasis were excluded. These patients were divided into either the high-risk or low-risk group for hereditary breast cancer by the ...
We analyse the expression of E-, N- and P-cadherin in a series of ductal carcinoma in situ (DCIS) of the breast, since this disease represents a heterogeneous group, with different risks of progression to invasive breast carcinoma. We also studied the correlation between cadherin expression ...
The Gleason grading system represents the main tool used for predicting the prognosis and guiding the therapy of patients affected by prostate cancer36. This system, however, is blind to the genomic makeup of the cells analyzed and to spatial genetic heterogeneity across different regions of the ...
prognosis for patients with invasive carcinoma21. Our comparison of two DCIS regions in Sample #1 reveals reduced myoepithelial markersKRT15,KRT23, andALDH1A3and increased invasive markers in DCIS #2 (Fig.4) which could indicate a higher grade tumor.ALDH1A3(a.k.a. RALDH3), which catalyzes ...
Non-palpable breast carcinomas consists a heterogeneous group of lesions with variable findings and different prognosis. Mammographically detected density is a risk factor for breast cancer and is attributed to alterations in the composition of breast tissue [5, 6]. Previous studies seeking to ...
ESR1 mutations in patients with ER-positive, HER2-negative breast cancer are associated with endocrine resistance, metastases, and poor prognosis. Selective estrogen degraders, such as fulvestrant, have displayed limited efficacy in this patient population. Lasofoxifene is a third-generation oral SERM ...
The differentially expressed proteins were cross-referenced with DNA microarray data obtained using the same cellular model and the overlapping genes were filtered for factors linked to poor prognosis in breast cancer gene expression meta-data sets, resulting in an HMGA1 protein signature composed of ...
However, high TIL levels have been associated with good prognosis and potential benefit with the use of immune checkpoint inhibitors, and approximately 15% of patients with mCRC have high TILs. POCHI was a single-arm, open-label, multicenter, proof-of-concept trial that enrolled patients at ...