Title: Appropriateness of Statin Dose in High Risk Patients Post-PCI/CABG at Gwinnett Medical CenterPrimary investigator: Brandon Cunningham, PharmDMentor: Mary George, PharmDBackground: American College of Cardiology (ACC)/American Heart Association (AHA) guidelines for cholesterol and acute coronary ...
Levels of HDL-C were modestly increased by 5% to 10% across both the every-2-weeks and the monthly dose groups (4%-10% vs placebo at the mean of weeks 10 and 12) (eTables 3 and 6 and eFigure 2 in Supplement). Baseline PSCK9 levels were higher in the high-intensity statin ...
showed that intensive but not regular-dose atorvastatin therapy resulted in regression of carotid atherosclerotic disease (Yu et al., 2007) and two magnetic resonance (MR) imaging studies have shown regression of the lipid core of atheromatous plaque after high-dose statin (Kramer et al., 2011,...
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The linear trapezoidal rule was used to calculate the area under each drug concentration‒time curve (AUC0–τ, µg h/L) from dosing to the end of the dosing interval (τ = 24 h). The apparent oral clearance (Cl/F) was calculated from the dose/AUC0–τ. Student’s t‐test...
However, a significant proportion of statin-treated patients remains at elevated risk of cardiovascular events, which has been referred to as “residual risk”4, 5. Besides, statins increased hemoglobin A1c (HbA1c) levels as well as the risk of new-onset diabetes in a dose-dependent manner6,...
Refametinib was readily absorbed following oral administration (plasma half-life of approximately 16 hours at the MTD), and pharmacokinetic parameters displayed near-dose proportionality, with less than 2-fold accumulation after multiple dosing. Another 30 patients were enrolled in the MTD cohort; 19...
Our conclusions are the same as those found in all four much smaller, randomized, placebo-controlled trials specifically designed to evaluate statin therapy in patients with cancer. Design of fixed dose combination and physicochemical characterization of enteric-coated bilayer tablet with circadian ...
At the last day of multiple dosing, blood samples were collected predose and up to 48 hours following dosing. Plasma pitavastatin was quantified by a validated liquid chromatography tandem mass spectrometry method. Tolerability was assessed by the adverse events, physical examination, 12-lead ECG, ...
dose, which may be determined by a skilled person according to standard methods, e.g. by in vitro experiments or in animal models. The composition is preferably administered by infusion, injection or inhalation. The dose of the active ingredient is determined according to the type and the ...