Eomes和T-bet也是可以这样分开。也就是说ILC1在两种小鼠中数量是没有差异的。还有其他比如免疫检验点抑制性受体PD-1、TIGIT、CTLA4也是这样上下分开的。 而细胞因子IFN-γ(Ifng)和激活受体CD69(Cd69)是只有在Hif1a-/-的第4群中表达...
为了避免由于活跃细胞分裂造成的偏差,我们专注于非增殖T细胞,并使用均匀流形近似和投影(UMAP)可视化的无监督聚类识别出六个主要的耗尽T细胞群体(图1a和补充图1b)。Tpex细胞的特征是活化(Cd44, Cd69, Icos),耗竭(Pdcd1, Tox)和记忆相...
CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognate antigen. We observed intense expression of CD69 on tumor-infiltrating T-lymphocytes that reside in the hypoxic tumor microenvironment and hypothesized that CD69 could be, at least partially, under th...
PD-1, perforin, Ly-6G, and CD69 stains were quantified by manual annotation of positively stained cells. Real-time PCR of mRNA and genomic DNA and recombination-specific genomic DNA PCR RNA was isolated from powdered frozen samples using the NucleoSpin RNA kit (Machery Nagel), cDNA prepared...
Mani和她的同事研究人永生化乳腺上皮细胞(HIMEL)时发现,TGF-β培养12天或转染Snail、Twist等诱导上皮细胞发生EMT后,细胞系中CD44+/CD24−细胞亚群比例升高,体外实验证实乳腺小球生成能力增强,提示EMT过程伴随着已分化细胞干细胞特性的获得[53]。肿瘤细胞与巨噬细胞等骨髓源细胞的融合以及药物处理的肿瘤细胞发生EMT...
We found that 5FU treatment significantly increased the CD44+/CD133+ CSC population. In contrast, this CSC population in CSC enriched spheres (CES) derived from HCT116 cells were decreased by combination of Orientin and 5FU. Decrease of CSC’s stemness properties was also noted, as evidenced...
did not test the effect of EZN-2208 treatment on HIF signaling or expression in patient samples. CRLX101 is a nanoparticle comprised of CPT, pendant carboxylic acid groups, and linear, cyclodextrin-polyethylene glycol (CD-PEG) blocks. In a model of subcutaneously implanted A2780 human ovarian ...
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Anti-mouse CD27-PE (LG.3A10) BioLegend RRID: AB_1236459 Anti-mouse CD69-BV421 (H1.2F3) BioLegend RRID: AB_10900250 Anti-mouse KLRG1-FITC (2F1) SouthernBiotech RRID: AB_2795367 Anti-mouse NKp46-PE-Cy7 (29A1.4) BioLegend RRID: AB_11219186 Anti-mouse IFN-γ-FITC/APC (XMG1.2) Bio...
3、流式细胞仪用试剂类,包括CD系列、细胞因子系列等; 4、乳胶手工及上机试剂,包括透光比浊检测试剂; 5、检测试剂盒,包括微色谱柱类检测试剂; 6、标记物检测试剂; 7、微生物传染病检测试剂,包括类及其它传染病类检测试剂; 8、实验室仪器类,包括BTS-330大屏幕半自动生化分析仪、MiniNeph微量蛋白散色比浊仪及相...