原文出处:Zhou Yang, Wei Su, Xiyi Wei, Shuang Qu, Dan Zhao, Jingwan Zhou, Yunjun Wang, Qing Guan, Chao Qin, Jun Xiang, Ke Zen, Bing Yao.HIF-1α drives resistance to ferroptosis in solid tumors by promoting la...
Furthermore, PS-NP treatment upregulated the expressions of HIF-1伪 and HO-1, and PS-NP-induced ferroptosis can be alleviated by inhibition of HIF-1伪 using si-HIF-1伪. This study provided an insightful reference for the intergenerational cardiotoxicity assessment of PS-NP.Ruiqiong Li...
HIF–1alpha inhibits ferroptosis and promotes malignant progression in non–small cell lung cancer by activating the Hippo–YAP signalling pathway. Oncol Lett. 2023;25:90. Article CAS PubMed PubMed Central Google Scholar Zou F, Li Y, Zhang S, Zhang J. DP1 (prostaglandin D(2) receptor 1)...
As a special form of cell death induced by iron-dependent lipid peroxidation, ferroptosis has been implicated in many diseases, such as carcinogenesis, degenerative disease. Recent studies indicated that HIF-1α induced to ferroptosis of bone cell, which is involved in osteoporosis genesis and ...
6 Effect of DMOG on cell viability (A) and ferroptosis (B) in HSC-T6 cells ( x s , n = 3) 质是 Fe2+介导下的脂质氧化物的代谢障碍,导致细 胞内铁超载,ROS 和脂质过氧化物堆积,破坏细胞 氧化还原平衡和质膜结构,触发细胞死亡[15].近年 来,本课题组和国内外多项研究表明,应用铁死亡 诱导...
heterogeneity is emphasized in cancer therapy [233]. Regarding cell proliferation, HIF-1α stabilization by USP14 is shown to impede cell proliferation under normoxia [170]. Additionally, HIF-1α SUMOylation via HSP70 knockdown inhibits A549 cell proliferation and ferroptosis after heat treatment [...
journal of hepatology(IF=30.083)的文章COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma阐明COMMD10抑制HIF1α/CP环,以增强HCC中Cu-Fe平衡...
E1A-associated 300-kDa protein (P300), an endogenous histone acetyltransferase, contributes to modifications of the chromatin landscape of genes involved in multiple cardiovascular diseases. Ferroptosis of vascular smooth muscle cells (VSMCs) is a novel
Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway Article Open access 01 March 2024 TBK1-medicated DRP1 phosphorylation orchestrates mitochondrial dynamics and autophagy activation in osteoarthritis Article 25 August 2022 SIRT3-PI...
SGLT2 inhibition mitigates transition from acute kidney injury to chronic kidney disease by suppressing ferroptosis Article Open access 02 September 2024 Inhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis Article Open access 12 December 2023 ...