目的:探究NF-κB/HIF-1α信号通路在慢性脑低灌注引起神经炎症过程中的作用及机制.方法:采用单侧颈总动脉永久性结扎(Unilateral Common Carotid Artery Occlusion,UCCAO)方法建立慢性脑低灌注小鼠模型,随机分为3大组,每组50只,分别为正常对照组,假手术组和UCCAO组,每大组按1 d,3 d,7 d,14 d,21 d分为5小组...
These two signaling pathways have many intersections, and NF-κB activation provides positive feedback on the regulation of HIF-1α and the formation of inflammatory response.常亚娟黄树明湛清扬吴丹张博Progress in Modern Biomedicine