The treatment of diastolic heart failure (HF), also known as heart failure with preserved systolic function (HFpEF), has been challenging, partly because there is a lack of consensus regarding the definition of the disease entity as well as a paucity of large-scale clinical trials to ...
even after correction for age, sex, body mass index, systolic blood pressure, hypertension treatment, cholesterol levels, diabetes mellitus, prior myocardial infarction, and valvular heart disease [8]. The main risk factor for progression in this study was airflow limitation which could be a manife...
Interventions, such as caloric restriction, and insulin-sensitizing or glucose-lowering agents, such as metformin, dipeptidyl peptidase-4 (DPP-4) inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists, all improve murine diastolic function [45]. In HFrEF patients, metabolic therapies tha...
P1462Masked hfpef in hypertensive patients with normal systolic and diastolic function at rest is more frequent in diabetic: a role of combined cardiopulmonary and stress-echocardiography testingdoi:10.1093/eurheartj/ehx502.P1462Banovic, M.Nedeljkovic, I....
Nonetheless, their clinical value has been studied across the whole spectrum of LV systolic function. Circulating levels of NPs are increased in patients with HFpEF and mirror the severity of cardiac morphological and functional abnormalities, such as LV hypertrophy, fibrosis and diastolic dysfunction [...