WB403 improved hyperglycemia of HFD/STZ mice.Chunbing ZhengWenbo ZhouTongtong WangPanpan YouYongliang ZhaoYiqing YangXin WangJian LuoYihua ChenMingyao Liu
395-P: QingReYiQiHuoXue Formula Attenuates Dyslipidemia and Ferroptosis in DKD HFD/STZ Micedoi:10.2337/db24-395-PBackground: Diabetic kidney disease (DKD), a common complication of diabetes, increasingly threatens patients. Approximately 20%-40% of diabetic patients develop DKD, with 30%-50% ...
In this study, we explored the effects and potential mechanism of AAPs on type 2 diabetes (T2D) using a high-fat diet and streptozotocin (STZ) induced C57BL/6J mice. The results indicated that 50 and 100mg/kg AAPs significantly decreased inflammation, liver injury, and insulin resistance. ...
In this work, we investigated the ameliorative effects of platycodin D (PD), a major active chemical ingredient isolated from the roots of Platycodon grandiflorum (PG), on high-fat diet (HFD)/streptozotocin (STZ)-induced type 2 diabetes (T2D) mice. PD treatment (2.5 and 5.0 mg kg1) ...
Methods: A murine model of T2DM was induced by high-fat diet (HFD) feeding combined with low-dose streptozocin (STZ) injections, and the diabetic mice were treated with THF by gavaging for consecutive 10 weeks. Fasting blood glucose (FBG), serum insulin, blood lipid, mitochondrial Ca2 (mCa...
LABORATORY miceNonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) plays a role in various diseases. Here, the anti-diabetic effects of NAG-1 were evaluated using a high-fat diet/streptozotocin-induced diabetic mouse model. NAG-1-overexpressing transgenic (NAG-1 Tg) mice exhibited ...
Tomatidine ameliorates high-fat-diet/streptozocin (HFD/STZ)-induced type 2 diabetes mellitus in miceView further author informationJuping HuView further author informationhoubaojian3080201@163.comBaojian HouView further author informationLi Cai
Methods: Type 2 diabetic mouse models were induced using high-fat diet (HFD) and streptozotocin (STZ), followed by IF treatment. Mice were then grouped for combined therapy with different doses of SLBZS and prebiotics. Fasting blood glucose (FBG) levels, body weight variations, and oral ...
伪 secretion, which impaired the NLRC4/IRF1 signaling in cardiomyocytes, and reduced further recruitment of macrophages, attenuated cardiac inflammation and hypertrophy, these effects were confirmed by silencing IRF1 in WT mice, and significantly reversed by overexpression of IRF1 in AIM2 -/- mice. ...
TRPM2 knockdown attenuates hyperglycemia-induced myocardial apoptosis and promotes autophagy in HFD/STZ-induced diabetic mice or HG-stimulated cardiomyocytes via regulating the MEK/ERK and mTORC1 signaling pathway.doi:10.1007/s11010-024-04926-0Feng Hu...