SFPs were proved to function as central mediators of reproductive fitness by interacting with female-derived molecules to modulate pivotal reproductive processes such as sperm competition, female receptivity, ovulation, and oogenesis. However, the underlying mechanisms o...
Keywords: hexokinase,drug targets, protein, function, Plasmodium falciparum,1.0 IntroductionHexokinase has been identified as an enzyme that catalyses the phosphorylation of glucose, this phosphorylation provides theactivation energy required for glycolysis. Hexokinase enables glucose taken up into muscle ...
2016. Post-translational Regulation of Hexokinase Function and Protein Stability in the Aestivating Frog Xenopus laevis. Protein J 35(1): 61-71.Childers CL, Storey KB. 2016. Post-translational regulation of hexokinase function and protein stability in the aestivating frog Xenopus laevis. Protein ...
Gene ontology (GO) based on the BP (biological process), and on the MF (molecular function) and KEGG pathway analyses were used to depict the functional annotations of these proteins in a bubble chart.Real-Time Quantitative PCR (RT-qPCR) analysis...
loss-of-function mutations causelong QT syndrome, a disease of prolongedcardiac repolarizationpredisposing toreentry arrhythmias. However, KCNQ1 is also expressed in other tissues, including pancreatic β-cells, where it regulatespotassium currentand thus, potentially, regulatesinsulin secretion. Single-nuc...
Hexokinase as a sugar sensor in higher plants. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function ...
This model is supported by the observation that several metabolic perturbations that inhibit hexokinase function, such as treatment with glucose-6-phosphate, 2-deoxyglucose, or citrate, all lead to inflammasome activation. How exactly hexokinase release from the mitochondrial outer membrane promotes NLRP...
The results suggest that the association of HKII with mitochondria is essential for IPC protective effects and normal cardiac function through maintenance of mitochondrial potential.doi:10.1136/heartjnl-2011-301156.7Smeele, K. M.Southworth, R.
The same .. Preparation of HEXOKINASEBackground and Overview HEXOKINASE (Hexokinase) is one of the key enzymes in the respiratory metabolism process of organisms and has the function of catalyzing the phosphorylation of hexose sugars. HE..
Given published reports on a possible cytoprotective role for HK3 [14,21] in AML cell lines, we investigated if complete loss of HK3 function in myeloid cells affects cellular viability rather than glycolysis. We found that the twoHK3-null clonal cell lines upon ATRA treatment by day 4 showed...