Mechanistically, combined proteomics and metabolic flux analysis reveals elevated hexokinase 2(HK2)-driven glycolysis in tumor pericytes, which up-regulates their ROCK2-MLC2 mediated contractility leading to impaired blood vessel supporting function. Clinically, high percentage of HK2 positive pericytes in ...
(VDAC1), which enhances glycolysis and regulates cellular energy metabolism through phosphorylation of glucose, and the substrate ATP produced byOXPHOSin mitochondria. An additional function of HK binding toVDAC1is to prevent VDAC1 from forming themitochondrial permeability transition pore(mPTP), thereby...
Keywords: hexokinase,drug targets, protein, function, Plasmodium falciparum,1.0 IntroductionHexokinase has been identified as an enzyme that catalyses the phosphorylation of glucose, this phosphorylation provides theactivation energy required for glycolysis. Hexokinase enables glucose taken up into muscle ...
In total, these findings are supportive of a role for HK3 in promoting DNA protection, which appears to be independent of its reported function in glycolysis. Transcriptomic analysis identifies activation of apoptosis, enhanced reactive oxygen species as well as DNA damage signatures in AMLHK3-null ...
Changes in glycolysis and respiration were measured after HK2 KD using the Seahorse metabolic analyzer. Measuring extracellular acidification rate (ECAR) with the Seahorse metabolic analyzer showed marked reductions in glycolytic function in both Huh7 and HepG2 cells upon HK2 loss compared to control ...
HEXOKINASE, with the chemical formula C6H12O6 and CAS registry number 9001-51-8, is an enzyme that plays a crucial role in glucose metabolism. It catalyzes the phosphorylation of glucose to glucose-6-phosphate, which is the first step in both glycolysis and glycogen synthesis. HEXOKINASE is ...
The first is an AtHXK1-dependent pathway in which gene expression is correlated with the AtHXK1-mediated signaling function. The second is a glycolysis-dependent pathway that is influenced by the catalytic activity of both AtHXK1 and the heterologous yeast Hxk2. The last is an AtHXK1-...
Gene ontology (GO) based on the BP (biological process), and on the MF (molecular function) and KEGG pathway analyses were used to depict the functional annotations of these proteins in a bubble chart.Real-Time Quantitative PCR (RT-qPCR) analysis...
Hexokinase is sugar sensor in higher plants Hexokinase as a sugar sensor in higher plants. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function ...
Activation of CD4 T cells leads to their metabolic reprogramming which includes enhanced glycolysis, catalyzed through hexokinase enzymes. Studies in some systems indicate that the HK2 isoform is the most up regulated isoform in activated T cells and in this report the relevance of this finding is ...