To solve the question regarding the inhibition of the enzyme hexokinase by excess glucose 6-phosphate, we can follow these steps:Step 1: Understand the Role of Hexokinase Hexokinase is an enzyme that catalyzes the conversion of
High rate of aerobic glycolysis is a hallmark of cancers which has promoted the development of aerobic glycolysis inhibitors and other novel drugs targeting metabolic enzymes to treat cancer [1]. Hexokinase (HK) is the first step of aerobic glycolysis that generates glucose-6-phosphate (G6P), wh...
To solve the analogy "hexokinase : transferase : : amylase : ………..", we need to identify the type of enzyme that amylase represents, just as hexokinase is classified as a transferase.1. Identify the Function of Hexokinase
(This article belongs to the Special Issue Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis)Download keyboard_arrow_down Browse Figures Versions Notes Abstract Hexokinase 2 (HK2), an enzyme of the sugar kinase family, plays a dual role in glucose metabolism and mediating ...
Decreases in Mondo A/Mlx/G6P transcriptional activity are also expected to decrease the expression of other ChRE-linked genes—TXNIP, lipogenic enzymes, and others (Figure 2)—which may improve glucose tolerance and decrease insulin resistance [113,130]. Interestingly, functional genomic studies ...
Infection of primary CD4+ T cells with HIV-1 coincides with an increase in glycolysis. We investigated the expression of glucose transporters (GLUT) and glycolytic enzymes in human CD4+ T cells in response to infection with HIV-1. We demonstrate the co-expression of GLUT1, GLUT3, GLUT4, ...