In adults and adolescents with recurrent clinical episodes of genital HSV infection that are frequent (eg, 4-6 times per year or more), that are severe, or that cause distress, the WHO sexually transmitted infection (STI) guidelines suggest suppressive therapy over episodic therapy and reassessment...
Herpes Simplex Virus Type 2 Suppressive Therapy with Acyclovir or Valacyclovir Does Not Select for Specific HIV-1 Resistance in HIV-1/HSV-2 Dually Infected PersonsRecent in vitro studies suggest that acyclovir may directly inhibit HIV-1 replication and can select for a specific HIV-1 reverse ...
HSV-2, suppressive therapy, inflammation, HIV-1/HSV-2 co-infectionBackgroundHerpes simplex virus type-2 (HSV-2) may heighten immune activation and increase HIV-1 replication, resulting in greater infectivity and faster HIV-1 disease progression. An 18-week randomized, placebo-controlled crossover...
The principal recommendations of the 2023 Korean STI guidelines in terms of viral infection follow: 1) If genital herpes recurs more than 4–6 times annually, suppressive therapy with acyclovir 400 mg orally 2 times/day or famciclovir 250 mg orally 2 times/day or valacyclovir 500 mg orally ...
There are several ways to transmit herpes, and different methods of suppressive therapy to reduce transmission. HSV-I and HSV-II HSV-1 and HSV-2 are two strains of the herpes virus. While HSV-1 usually presents as an oral infection, it can spread to the genitals through oral-genital conta...
If you have frequent or severe herpes outbreaks, your medical professional may recommend taking an antiviral medication every day, called suppressive therapy, to decrease the frequency and severity of outbreaks. This type of therapy may also be effective in decreasing the chance that an uninfected ...
Herpes simplex virus (HSV) is one of the most common, yet frequently overlooked, sexually transmitted infections. Since the type of HSV infection affects prognosis and subsequent counseling, type-specific testing to distinguish HSV-1 from HSV-2 is recommended. Although PCR has been the diagnostic ...
Acyclovir and Valacyclovir can be used to treat herpes infections once symptoms are already present, but both can also be taken in daily regimens as part of suppressive therapy. The dosage of a daily regimen is typically smaller (i.e., one 500mg pill daily versus three 1g pills at the fir...
Herpes simplex virus (HSV) infections are ubiquitous and have a wide range of clinical manifestations (see the images below). Beyond the neonatal period, most primary HSV-1 infections occur in infancy and childhood and are transmitted primarily by contac
Other people have recurrent infections that are frequent enough or severe enough to justify suppressive therapy, in which medications are taken every day to decrease the frequency and severity of attacks. Visit Urgency If you develop tender, painful sores in the mouth or on the lips or nose, se...