, and Lynch, H. , Hereditary breast cancer: pathobiology, prognosis, and BRCA 1 and BRCA 2 gene linkage . Cancer , 77 , 697 – 709 ( 1996 ). TODO: clickthrough URL MedlineMarcus JN, Watson P, Page DL et al. Hereditary breast cancer: Pathobiology, prognosis and BRCA1 and BRCA2 ...
The hereditary breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, have established roles in genome integrity maintenance and in the control of homologous recombination. Recent work has produced valuable insights into the mechanisms of action of the gene products. This review summarizes so...
If you do not have a gene mutation, testing can be a relief if breast or ovarian cancer runs in your family. You could still develop cancer, but your risk is the same as any woman's who does not have a BRCA mutation. You may also feel relief to know that you will not pass the ...
Family I - breast cancer syndrome; 9 breast cancer cases were diagnosed in women between 25 and 45-year-of-age from 4 generations. The BRCA1 5382insC mutation was found in family members. Family II - hereditary nonpolyposis colon cancer; altogether 17 cancers in 12 persons from 6 ...
遗传性乳腺癌 - 卵巢癌综合征(hereditary breast and ovarian cancer syndrome, HBOCS) 该综合征约占遗传性乳腺癌病例的 60%-75%。乳腺癌患者中约有 2%-5% 的肿瘤是因 BRCA 基因突变导致,卵巢癌中该比例更是高达 10%-15%。HBOCS 的女性患者其一生都有很高的乳腺癌和卵巢癌的发病风险,且对侧患乳腺癌的风险...
Breast cancer in BRCA1 and BRCA2 gene-mutation carriers may differ from so-called sporadic breast cancer in clinical features and behavior. These potential differences may be of importance for the prevention, screening, and, ultimately, treatment of breast cancer in women with such germline mutation...
Hereditary Breast Cancer: Part I. Diagnosing Hereditary Breast Cancer Syndromes Hereditary breast cancer (HBC) accounts for as much as 10% of the total BC burden. Most of these cases will be found to be due to a BRCA germline mutation... HT Lynch,E Silva,C Snyder,... - 《Breast Journa...
The hereditary breast-OC (HBOC) syndrome, with mutations in the breast cancer (BC)-associated genes BRCA1 and BRCA2, accounts for some 65–85% of all hereditary EOCs; Lynch syndrome (LS), with mutations in mismatch repair (MMR) genes (MLH1, MSH2, MSH6, PMS2), accounts for another 10...
Key Words: hereditary breast and ovarian cancer, BRCA1, BRCA2 NATURAL HISTORY AND GENETICS Disease characteristics Germline mutations in breast cancer 1 gene (BRCA1) and breast cancer 2 gene (BRCA2) predispose to breast and ovarian cancer as well as other cancers. The risk of developing cancer...
In order to understand the molecular basis of familial breast cancer, English literature identified through Medline between 1995 and February 2000 were reviewed using the search terms: breast cancer, genetics, hereditary, BRCA1 and BRCA2, amongst others. In this brief overview, some of the ...