my colleagues and I who specialize in the treatment of this disease all have a few such patients who have been rendered disease-free for prolonged periods of time — challenging that dogma. Regardless, even for the many patients who have HER2-positive ...
my colleagues and I who specialize in the treatment of this disease all have a few such patients who have been rendered disease-free for prolonged periods of time — challenging that dogma. Regardless, even for the many patients who have HER2-positive metastatic breast cancer who are...
my colleagues and I who specialize in the treatment of this disease all have a few such patients who have been rendered disease-free for prolonged periods of time — challenging that dogma. Regardless, even for the many patients who have HER2-positive metastatic breast cancer who are...
HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive casesHER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive casesdoi:...
Cellular biology Metabolomic analysis of her2-positive breast cancer cells CALIFORNIA STATE UNIVERSITYFRESNO Jason A. Bush SahniMalika KaurThe distinctive nature of HER2-positive breast cancers is marked by overexpression of the HER2 receptor and little is known about the role of HER2 on cellular ...
HER2 positive breast cancerAmplification and/or overexpression of human epidermal growth factor receptor 2 (HER2) are observed in 15鈥 20% of breast cancers (HER2+ breast cancers), and anti-HER2 therapies have significantly improved prognosis of patients with HER2+ breast cancer. One resistance ...
[1] Harbeck N, Gnant M. Breast cancer. Lancet. 2017;389:1134–1150. [2] Najminejad Z, Dehghani F, Mirzaei Y, et al. Clinical perspective: Antibody-drug conjugates for the treatment of HER2-positive breast cancer. Mol Ther. 2023;31(7):1874-1903. ...
A more comprehensive understanding of the signaling network downstream of HRG, in HER2-positive breast cancer cells, will be crucial for further development of inhibitors that do not elicit resistance. This study assessed HRG signaling in the HER2-positive breast cancer cell lines BT474 and SKBR3....
miR-342-5p specifically inhibited HER2-positive cell growth, as it had no effect on the growth of HER2-negative control cells in vitro. Furthermore, higher expression of miR-342-5p was associated with better survival in both breast cancer patient cohorts. In conclusion, we have identified ...
First, StARD3 overexpression, as measured by quantitative real-time PCR, increased the prognostic power of ErbB2 overexpression for disease-free survival of breast cancer patients.17 Second, knockdown of StARD3 by siRNA in HER2-positive breast cancer cell lines (both trastuzumab-responding cell ...