阴阳表里不一:HER2阴性肿瘤可表达HER2胞内域并呈现HER2阳性表型 Cancer Lett. 2015 Feb 1;357(1):186-95. The positive is inside the negative: HER2-negative tumors can express the HER2 intracellular domain and present a HER2-positive phenotype. Panis C, Pizzatti L, Corrêa S, Binato R, Lemos ...
Bose R, Kavuri SM, Searleman AC, et al. Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov. 2013;3(2):224-237. Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(74):61-70 Endo Y, Dong Y, Kondo...
T-DXd在真实世界中亦显示出可管理的安全性,一项研究在HER2+和HER2低表达转移性肿瘤患者中评估T-DXd的真实世界安全性和停药率,研究11显示,T-DXd因治疗相关不良事件导致的停药率为9%,显著低于DESTINY-Breast04研究报告的16.2%(P=0.045)。间质性肺...
The HER2-negative breast cancer cell line, MCF-7, transfected to express CTF-611, showed exclusively red staining (ICD signal), confirming accurate detection of truncated HER2 generated by alternative translation initiation (Figure 1B). Compared with formalin-fixed cell-line pellets, breast cancer ...
13. Cheung A, Opzoomer J, Ilieva KM, Gazinska P, Hoffmann RM, Mirza H, et al. Anti-Folate Receptor Alpha-Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer. Clin Cancer Res 2018; 24(20):5098-5111.
Recently, a vaccine consisting of a peptide derived from the extracellular domain of HER2 (E75 peptide (HER2 369–377)) mixed with GM-CSF was administered at various doses and schedules to patients with resected node positive and node negative breast cancer. All patients demonstrated in vivo ...
Many previous epidemiologic studies showed that recent BMI was inversely associated with premenopausal women’s risk of breast cancer overall and hormone receptor positive breast cancer, but not with hormone receptor negative breast cancer or TNBC [3, 5]; however, not many of these studies adjusted...
Cancer Cell signalling Oncogenes Senescence This article is cited by Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer Xiaoxi Li Nan Su Shu-lan Sun Cell Communication and Signaling (2024) Hypoxic glioblastoma-cell-derived ...
Therefore, we hypothesized that suboptimal vitamin D levels may compromise the efficacy of CDK4/6i used to treat hormone receptor (HR)-positive, HER2-negative metastatic breast cancer (MBC).Methods:We conducted a retrospective single-center study of women diagnosed with HR-positive, HER2-negative ...
Ross et al., “The HER-2/neu Gene and Protein in Breast Cancer2003: Biomarker and Target of Therapy,” The Oncologist, 2003, 8(4):307-325, 19 pages. Sapino et al., “Patients with advanced stage breast carcinoma immunoreactive to biotinylated Herceptin® are most likely to benefit from...