Bose R, Kavuri SM, Searleman AC, et al. Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov. 2013;3(2):224-237. Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(74):61-70 Endo Y, Dong Y, Kondo...
阴阳表里不一:HER2阴性肿瘤可表达HER2胞内域并呈现HER2阳性表型 Cancer Lett. 2015 Feb 1;357(1):186-95. The positive is inside the negative: HER2-negative tumors can express the HER2 intracellular domain and present a HER2-positive phenotype. Panis C, Pizzatti L, Corrêa S, Binato R, Lemos ...
另一项T-DXd治疗转移性乳腺癌的中枢神经系统(CNS)疗效的单中心、真实世界分析10表明,T-DXd在HER2+和HER2低表达转移性乳腺癌的CNS疗效相似,远低于既往前瞻性临床试验的报道。 T-DXd在真实世界中亦显示出可管理的安全性,一项研究在HER2+和HER2低表达...
The HER2-negative breast cancer cell line, MCF-7, transfected to express CTF-611, showed exclusively red staining (ICD signal), confirming accurate detection of truncated HER2 generated by alternative translation initiation (Figure 1B). Compared with formalin-fixed cell-line pellets, breast cancer ...
Many previous epidemiologic studies showed that recent BMI was inversely associated with premenopausal women’s risk of breast cancer overall and hormone receptor positive breast cancer, but not with hormone receptor negative breast cancer or TNBC [3, 5]; however, not many of these studies adjusted...
Therefore, we hypothesized that suboptimal vitamin D levels may compromise the efficacy of CDK4/6i used to treat hormone receptor (HR)-positive, HER2-negative metastatic breast cancer (MBC).Methods:We conducted a retrospective single-center study of women diagnosed with HR-positive, HER2-negative ...
13. Cheung A, Opzoomer J, Ilieva KM, Gazinska P, Hoffmann RM, Mirza H, et al. Anti-Folate Receptor Alpha-Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer. Clin Cancer Res 2018; 24(20):5098-5111.
It is noteworthy to compare these results with another HER2 directed therapy in which the concept of prolonged immunity and its application to the adjuvant treatment setting was recently explored in patients with resected node positive and node negative breast cancer [13]. A vaccine consisting of a...
Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer Xiaoxi Li Nan Su Shu-lan Sun Cell Communication and Signaling (2024) Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages Stoyan ...
While HER2 over-expression was initially associated with the most guarded prognosis in breast cancer (BrCa), the advent of a targeted anti-HER2 therapy, has resulted in women with these HER2 positive tumors having one of the most favorable prognoses [10]. Like BrCa, high grade EnCa, including...