1区)期刊《Breast Cancer Research》正式发表发表题为“Detection of HER2 expression using 99mTc-NM-02 nanobody in patients with breast cancer: a non-randomized, non-blinded clinical trial”的论文。
纳米抗体(nanobody,Nb), 即重链单域抗体VHH (variable domain of heavy chain of heavy-chainantibody) ,该类抗体只包含一个重链可变区(VHH)和CH2,CH3区,相比于其他抗体,轻链天然缺失。纳米抗体晶体直径2.5nm,长4nm,是自然存在的可以和抗原结合的最小片段。 纳米抗体和传统抗体的优劣对比: 纳米抗体的应用: 纳米...
中文名称:抗 Human CD340/ERBB2/HER2 纳米抗体 (SAA0836)(RHC09601)英文名称:Anti-Human CD340/ERBB2/HER2 Nanobody (SAA0836) 纯度规格:PAGE:>95%产品类别:一抗 InVivo活性抗体 抗体名:Anti-Human CD340/ERBB2/HER2 Nanobody (SAA0836)靶点:CD340/ERBB2/HER2 ...
纳米抗体(nanobody),也被称之为单域抗体(single-domain antibodies,sdabs),是近年来新发现的新型抗体,它本质上是一种特异结合抗原的单一重链可变区(variabledomain of heavychain of heavy-chain antibody,vhh)。基于纳米抗体构建双(多)特异性抗体是发展方向之一。 4、然而,目前本领域还缺乏靶向her2的、能抑制her2...
The resulting HER2 Nb-poly(Rha) demonstrated superior capacity in recruiting anti-rhamnose antibodies from serum compared to HER2 nanobody conjugated with monovalent rhamnose (HER2 Nb-Rha). Nanobodies, with their stability, specificity, and low immunogenicity, offer a versatile tool for targeting ...
[3] Keyaerts M, Xavier C, Heemskerk J, et al. Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma. J Nucl Med. 2016 Jan;57(1):27-33. doi: 10.2967/jnumed.115.162024.[4] Zhao L, Liu C, Xing Y, et al. Development of a 99mTc-...
2.3 HER2靶向Nanobody核素探针 除此以外,与北京大学医学贾兵教授团队合作,在 欧洲核医学与分子影像 (EJNMMI)杂志上发表了一种氟-18标记的HER2特异性纳米抗体RESCA‑MIRC213的制备方法及其用于HER2阳性病灶的靶向诊断的研究。 研究发表了氟-18常温标记纳米抗体的策略,[ 18 F]AlF‑RESCA‑MIRC213的临床前研究结果...
[3] Keyaerts M, Xavier C, Heemskerk J, et al. Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma. J Nucl Med. 2016 Jan;57(1):27-33. doi: 10.2967/jnumed.115.162024. [4] Zhao L, Liu C, Xing Y, et al. Development of a 99mTc-La...
2例原发灶为阴性的转移灶出现高摄取,可能是因为原发灶与转移灶HER2表达的不一致。18F为目前生产使用最为广泛的正电子核素,亦可用于相关抗体的标记,Xaviera等进行了18F-FB-anti-HER2 Nanobody在HER2阳性肿瘤移植鼠的体内显像研究,结果表明该探针具有较高的肿...
[18F]AlF‑RESCA‑ MIRC213:a18F‑labeled nanobody as PET radiotracer for diagnosis of HER2‑positive cancers([18F]AlF‑ RESCA‑MIRC213 在临床前和首次人体实验中的活体内稳定性:一种18F标记的纳米体作为HER2阳性癌症诊断的PET放射性示踪剂)在学术期刊European Journal of Nuclear Medicine and ...