HER2HER3LapatinibNumerous clinical trials support the biological relevance of the HER2 oncoprotein in breast cancer. In spite of improved outcomes, overexpression of the receptor is associated with increased risks of disease relapse, even in patients with early, and potentially curable, disease. Until ...
Human epidermal growth factor receptor 1 or 2 (HER1/2), and fibroblast growth factor receptor 1 (FGFR1) signaling serve critical roles in the progression of breast cancer; however, cross-talk between HER1/2 and FGFR1 signaling has not been extensively studied. In the present study, the copy...
目的:探讨HER1和HER2蛋白表达在乳腺癌发病中的相关性及其意义。方法:收集我院2013年4月至2015年2月就诊治疗的乳腺癌的患者106例,通过免疫组化的方法检测所有患者的HER1和HER2蛋白表达情况,运用统计分析的方法,分析以上两种蛋白与乳腺癌之间的相关性。结果:HER-1及HER-2蛋白在不同种类、不同分期以及不同年龄段的乳...
In addition, presence of HER4 in HER2-expressing tumours reduced the recurrence in breast cancer patients, further supporting the distinct roles for EGF family receptors (Barnes et al, 2005). EGF receptors and bladder cancer survival AA Memon et al 1704 It has been demonstrated that EGF ...
5 As dysregulated expression of human epidermal receptor (HER) family members is frequent in breast cancer, and given their crucial role in proliferation,9 these receptors have been extensively investigated as targets for anticancer therapy, particularly HER1, HER2 and HER3. HER1 overexpression is ...
Nimotuzumab (CIMAher®)(Center of Molecular Immunology, Cuba) HER1 Squamous cell carcinoma of head and neck, pediatric and adult malignant glioma, and pancreatic cancer [49] Trastuzumab (Herceptin®)(Genentech, Inc., EEUU) HER2 Metastatic HER2-overexpressing breast cancer and metastatic HER2-over...
Determinants of Transcription of the Chorionic Gonadotropin /Luteinizing Hormone Receptor Gene in Human Breast Cells. ▪: :Epidemiological evidence suggests that the earlier in life a woman becomes pregnant, the lower her chances for developing breas...
Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss HER2/neuis a member of the epidermal growth factor receptor family easily detectable in the serum of cancer patients. We aimed to evaluate circulating HER-... JM Fernández-Real,JA Menendez,G Frühbeck...
乳腺癌(breast cancer)是指发生于乳腺导管上皮细胞的恶性肿瘤,是女性常见的肿瘤之一,约占全身恶性肿瘤的7%-10%,全世界每年新发乳腺癌约150万例,死亡约57万例.北美,欧洲等西方发达国家为高发区,其发病率为亚,非,拉地区的4倍左右.我国虽属乳腺癌低发区的国家,但近20年来发病率有增高趋势,特别是在北京,上海等...
In this work, two human epidermal growth factor receptors, HER-1 and HER-2, were selected as biomarkers to enable the detection of breast cancer. Therefore, two biosensors were developed using gold sensor chips coupled with amperometric detection of the enzyme label horse radish peroxidase (HRP)...