[3]Evans DG, Phillips KA, Milne RL, et al. Survival from breast cancer in women with a BRCA2 mutation by treatment. Br J Cancer. 2021 Apr;124(9):1524-1532. [4]Giaquinto AN, Sung H, Miller KD, et al. Breast Cancer Statistics, 2022. CA Cancer J Clin. 2022 Nov;72(6):524-541...
[8]Dybdal N,Leiberman G,Anderson S,et al.Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab.Breast Cancer Res Treat.2005;93:3–11...
Breast cancer is the uncontrolled, abnormal growth of malignant breast tissue affecting predominantly women. The Human Epidermal Growth Factor Receptor 2 (HER2) is over expressed in approximately 20 % to 25 % of invasive breast cancer. HER2 status is a predictive factor that is taken into ...
Oncologic dogma maintains that women who have metastatic breast cancer will not be cured. However, my colleagues and I who specialize in the treatment of this disease all have a few such patients who have been rendered disease-free for prolonged periods ...
[4]Giordano SH, Buzdar AU, Smithet TL, al. Is breast cancer survival improving? Cancer. 2004;100(1):44-52. [5]Dawood S, Broglio K, Buzdar AU, et al. Prognosis of women with metastatic breast cancer by HER2 sta...
in the clinical trials that have gotten us where we are in the treatment of HER2-positive cancers. The ongoing and planned areas of research in this field will continue to lead us into the future in which even more women with HER2-positive breast cancer will live longer or even be cured....
Drs. Ullrich and Slamon were the first to report that amplification and overexpression of ERBB2 is associated with a worse prognosis for women with breast cancer. At the same time, investigators at Genentech had generated a set of mouse monoclonal antibodies against the protein. One of these, ...
The outcome of women with early breast cancer (BC) has gradually improved in the last 15 years following the introduction of trastuzumab and subsequently dual blockade (trastuzumab-pertuzumab or trastuzumab followed by neratinib) [1, 2]. In the latest pivotal adjuvant trial, Aphinity, in which 60...
We have made progressonearly cancerdetection in order to provide treatment at an early stage, particularly for women with uterineorbreast cancer. daccess-ods.un.org daccess-ods.un.org 在早发现早治疗癌症、特别是妇女惟患的卵巢癌 和乳腺癌方面,我们取得了进展。
Semiglazov V, Srimuninnimit V, Bianchi G, Szado T, Ratnayake J, Ross G, Valagussa P (2012) Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase...