“HER2 expression identifies dynamic functional states within circulating breast cancer cells.” Nature vol. 537,7618 (2016): 102-106. doi:10.1038/nature19328 Rugo, Hope S et al. “Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive Advanced Breast Cancer: A Phase...
Front Mol Biosci. 2022;9: 847835. 2. Implementing antibody-drugconjugates (ADCs) in HER2-positive breast cancer: state of the art and futuredirections. Breast Cancer Res. 2021; 23: 84. 更多生物制药知识尽在微信公众号"小药说药", 欢迎大家关注阅览!
BRCA1/2基因突变,导致其抑制肿瘤发生的功能受到影响。研究表明,5%~10%的乳腺癌患者具有明确的遗传基因突变,称之为遗传性乳腺癌(hereditary breast cancer,HBC),其中BRCA1/2基因突变占15%。 携带BRCA1/2基因突变的女性不仅乳腺癌发病风险增加,其他如卵巢癌、输卵管癌、胰腺癌、胃肠癌及黑素瘤等发病风险也增加,男性...
HER-2-positive breast cancer: hope beyond trastuzumab. Biodrugs 2007; 21(2): 69–77Bartsch R, Wenzel C, Zielinski CC, Steger GG. HER-2-positive breast cancer: hope beyond trastuzumab. BioDrugs. 2007;21:69–77.Bartsch R, Wenzel C, Zielinski CC, et al.: HER-2-positive breast cancer:...
"Every two minutes, a woman is diagnosed with breast cancer in the United States. On June 21st, I became one of them," she wrote in a social media post shared Wednesday morning. "As we approach #BreastCancerAwarenessMonth, I wanted to share my personal story with you all and encourage ...
[5]Erika Paige Hamilton et al., Clinical activity of MCLA-128 (zenocutuzumab), trastuzumab, and vinorelbine in HER2 amplified metastatic breast cancer (MBC) patients (pts) who had progressed on anti-HER2 ADCs.. JCO...
Breast cancer awareness holds a special place in my heart, particularly because I am a breast cancer survivor. This personal connection has deepened my commitment to raising awareness for all my patients.Recently, I had the opportunity to be interviewed by Women’s Health, where I discussed the...
号外号外,每周三的清晨,我们将推出全新的栏目,医海蠡测。如果我们把breast cancer 作为关键词,在pubmed上搜索近5年的文献,结果是353897篇,2017年就有21231篇,面对海量的文献,通读已不可能。在浩如烟海的文献中,通过兴趣,通过研究方...
The formerTODAYco-anchor talks about her breast cancer diagnosis. ByKatie Couric Media CancerPublished:October 3, 2022 Nate Congleton/NBC In anin-depth, heartfelt essay, Katie recently revealed that she was diagnosed withbreast canceron June 21, 2022. In the essay, she details how a long ...
HER-2 is a tyrosine kinase receptor which is overexpressed in 20-25% of breast cancer patients and is associated with poor prognosis. Trastuzumab, a humanized monoclonal antibody directed against the HER-2 receptor, used alone or in combination with chemotherapy, has shown significant clinical benef...