Xu B, Li W, Zhang Q, et al. Pertuzumab, trastuzumab, and docetaxel for Chinese patients with previously untreated HER2-positive locally recurrent or metastatic breast cancer (PUFFIN): a phase III, randomized, double-blind, placebo-controlled study. Breast Cancer Res Treat. 2020 Aug;182(3):68...
Malignant neoplasm of breasttrastuzumab蛋白质酪氨酸激酶HER-2 is a tyrosine kinase receptor which is overexpressed in 20-25% of breast cancer patients and is associated with poor prognosis. Trastuzumab, a humanized monoclonal antibody directed against the HER-2 receptor, used alone or in combination ...
BRCA1/2基因突变,导致其抑制肿瘤发生的功能受到影响。研究表明,5%~10%的乳腺癌患者具有明确的遗传基因突变,称之为遗传性乳腺癌(hereditary breast cancer,HBC),其中BRCA1/2基因突变占15%。 携带BRCA1/2基因突变的女性不仅乳腺癌发病风险增加,其他如卵巢癌、输卵管癌、胰腺癌、胃肠癌及黑素瘤等发病风险也增加,男性...
Jordan, Nicole Vincent et al. “HER2 expression identifies dynamic functional states within circulating breast cancer cells.” Nature vol. 537,7618 (2016): 102-106. doi:10.1038/nature19328 Rugo, Hope S et al. “Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive ...
[2] Pernas S, Tolaney SM. Clinical trial data and emerging strategies: HER2-positive breast cancer. Breast Cancer Res Treat. 2022 Apr 9. [3] 生物类似药研发与评价技术指导原则(试行) [4] NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Breast Cancer,NCCN Guidelines for Patien...
号外号外,每周三的清晨,我们将推出全新的栏目,医海蠡测。如果我们把breast cancer 作为关键词,在pubmed上搜索近5年的文献,结果是353897篇,2017年就有21231篇,面对海量的文献,通读已不可能。在浩如烟海的文献中,通过兴趣,通过研究方...
Shannen Doherty has revealed that her breast cancer diagnosis has returned.During an interview with ABC News which aired Tuesday on “Good Morning America,” Doherty said she’s at “stage four,” adding that “it’s a bitter pill to swallow in a lot of ways.”Doherty was initially diagnose...
结合多基因检测工具的验证研究及不同工具在中国的可及性,本共识将主要推荐以下工具:Oncotype Dx®(21个基因)、MammaPrint®(70个基因)、RecurIndex®(28个基因)和Breast Cancer Index®(BCI,7个基因,表1)。 多基因检测指导T...
"Every two minutes, a woman is diagnosed with breast cancer in the United States. On June 21st, I became one of them," she wrote in a social media post shared Wednesday morning. "As we approach #BreastCancerAwarenessMonth, I wanted to share my personal story with you all and encourage ...
Aliabadi helped her detect her breast cancer using the tool. The calculator is also how Dr. Aliabadi discovered her own cancer, in 2019, at the age of 49. Her mammogram had shown atypical cells, but her doctors said a biopsy showed no cancer present. ...