Hepatocellular carcinoma (HCC) is subclassified into five gross types, namely, vaguely nodular (VN), single nodular (SN), single nodular with extranodular growth (SNEG), confluent multinodular (CM), and infiltrative (INF) type. However, the pathological background underlying differences in ...
Okuda K, Peters R, Simson IW: Gross anatomic features of hepatocellular carcinoma from three disparate geographic areas. Cancer 54:2165–2173, 1984 Shikata T: Primary liver carcinoma and liver cirrhosis. In: Hepatocellular carcinoma. K Okuda, RL Peters (Eds). New York, Wiley Medical, 1976, pp...
78. Gross-Goupil, M. et al. Analysis of chromosomal instability in pulmonary or liver metastases and matched primary hepatocellular carcinoma after orthotopic liver transplantation. Int. J. Cancer 104, 745–751 (2003). 79. Calvisi, D. F., Factor, V. M., Ladu, S., Conner, E. A. & ...
Hepatocellular carcinoma (HCC) is a lead cause of cancer-related deaths. In the present study we investigated the role of Brahma-related gene 1 (BRG1), a chromatin remodeling protein, in HCC the pathogenesis focusing on identifying novel transcription targets. Methods and materials Hepatocellular car...
Fibrolamellar carcinoma (FLC) is a rare variant of primary liver malignancy with unique clinical, histological, and biological characteristics. It was first reported as a separate entity by Hugh Edmondson in 1956, who described the typical gross and microscopic features of this neoplasm as “a liver...
Hai-Qing Wang4,Yi-Jing Cai1,2, Li Ying3, Mei Song1,2, Yu-Qun Wang1,2, Shan-Jie Du1,2, Ke-Qing Shi1,2 & Meng-Tao Zhou5 Aberrant activation of DNA repair is frequently associated with tumor progression and response to therapy in hepatocellular carcinoma (HCC). Bi...
Comprehensive and integrative genomic characterization of hepatocellular carcinoma Cell, 169 (2017), pp. 1327-1341.e23 Google Scholar 47 E. Cerami, J. Gao, U. Dogrusoz, B.E. Gross, S.O. Sumer, B.A. Aksoy, A. Jacobsen, C.J. Byrne, M.L. Heuer, E. Larsson, Y. Antipin, B. Reva...
Hepatocellular carcinoma can be classified into three types based on gross morphological characteristics: nodular, massive, or diffuse [4]. Although the nodular and massive types constitute the majority of HCC lesions, diffuse-type HCC still accounts for 7 to 13% of cases [5, 6]. Worldwide, ...
Hepatocellular carcinoma (HCC) is among the most common malignancies worldwide and is characterized by high rates of morbidity and mortality, posing a serious threat to human health. Interventional embolization therapy is the main treatment against middle- and late-stage liver cancer, but its efficacy...
In addition, a number of subtypes are discussed in this chapter, along with typical hepatocellular carcinoma. This chapter examines the clinical, gross, and microscopic features of hepatocellular carcinoma and its variants with illustrated examples. The differential diagnosis of hepatocellular carcinoma is...