The role of Niemann-Pick disease type C protein 1 (NPC1) in liver cancer is underexplored. Here the authors report that NPC1 prevents ubiquitylation and degradation of TGF-β receptor 1, leading to activation of the TGF-β pathway and hepatocellular carcinoma progression. ...
Correlation Between Dynamic Contrast-Enhanced CT Imaging Signs and Differentiation Grade and Microvascular Invasion of Hepatocellular Carcinoma Liu Y, Zhou Y, Liao C, Li H, Zhang X, Gong H, Pu H Journal of Hepatocellular Carcinoma2025, 12:1-14 ...
Hepatocellular carcinoma (HCC) is one of the common malignant tumors worldwide. In 2020, there were 905,677 new cases and 830,180 deaths of HCC globally, ranking sixth and third in morbidity and mortality, respectively, and imposing a substantial disease burden [1]. Due to the subtle early ...
Normalvs.Hepatocellular Carcinomavs.MetastasisvsHemangiomas. However, very little work has been done on disease progression and severity scoring for diseases.
Impact of sex on the survival of patients with hepatocellular carcinoma: a surveillance, epidemiology, and end results analysis. Cancer 120, 3707–3716 (2014). Article PubMed Google Scholar Mittal, S. et al. Temporal trends of nonalcoholic fatty liver disease-related hepatocellular carcinoma in ...
Chemi F, Rothwell DG, McGranahan N, Gulati S, Abbosh C, Pearce SP, et al. Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nat Med. 2019;25(10):1534–9. Lu X, Tan S, Wu M, Ju H, Liang X, Li P. Evaluation of a new magnetic bead...
Immune Checkpoint Inhibitor Treatment in Patients With Advanced Hepatocellular Carcinoma (HCC) and Child-Pugh B Liver Function View LargeDownload Squares indicate estimates; size of squares, study weights; whiskers, 95% CIs; diamonds, mean estimates; DCR, disease control rate; OR, odds ratio; and ...
Efficacy by Baseline Hepatocellular Carcinoma (HCC) Etiology and PD-L1 Status eTable 4. Overall Survival Rates eTable 5. Objective Response Rate, Best Overall Response, and Disease Control Rate for All Patients eTable 6. Treatment-Related and Immune-Mediated Adverse Events eTable 7. Treatment-...
CSCs (Cancer stem cells) with distinct metabolic features are considered to cause HCC (hepatocellular carcinoma) initiation, metastasis and therapeutic resistance. Here, we perform a metabolic gene CRISPR/Cas9 knockout library screen in tumorspheres deri
Methytransferase-like proteins 9 (METTL9) has been characterized as an oncogene in several cancers, however, its role in hepatocellular carcinoma (HCC) remains unknown. Here, we investigated the function and molecular mechanism of METTL9 in HCC. We showe