Background: Hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are respectively the first and the second most common pediatric malignant liver tumors. The purpose of this study was to evaluate the combined use of the ultrasound examination and the assessment of the patients' clinical features fo...
Management of unresectable pediatric hepatoblastoma (HB) and hepatocellular carcinoma (HCC) remains challenging. The Society of Pediatric Liver Transplantation (SPLIT) database was used to study survival predictors in pediatric liver transplantation (LT) for HB and HCC. Event‐free survival (EFS), ...
Background and aims: One-third of hepatocellular carcinomas (HCCs) have mutations that activate the β-catenin pathway with mostly CTNNB1 mutations. Mouse models using Adenomatous polyposis coli (Apc) loss-of-functions (LOF) are widely u... R Loesch,S Caruso,V Paradis,... - 《Biorxiv》 ...
In hepatocellular carcinoma, PIM3 expression was increased in the tumors of those who received chemotherapy and PIM3 induced multi-drug resistance in vitro30. Since PIM3 expression was increased in the cisplatin-resistant cells, we sought to determine whether combining the pan-PIM inhibitor, AZD1208...
In hepatocellular carcinoma, PIM3 expression was increased in the tumors of those who received chemotherapy and PIM3 induced multi-drug resistance in vitro30. Since PIM3 expression was increased in the cisplatin-resistant cells, we sought to determine whether combining the pan-PIM inhibitor, AZD1208...
Pediatric hepatoblastoma is the most common primary liver cancer in infants and children. Studies of hepatoblastoma that focus exclusively on tumor cells demonstrate sparse somatic mutations and a common cell of origin, the hepatoblast, across patients.
High-intensity focused ultrasound combined with transarterial chemoembolization for unresectable hepatocellular carcinoma: long-term follow-up and clinical analysis Eur J Radiol, 80 (2011), pp. 662-669 View PDFView articleView in ScopusGoogle Scholar [14] J.E. Kennedy High-intensity focused ultrasound...
hepatocellular carcinomaliver transplantationoutcomespediatricPurpose Improvement in outcomes of LT for pediatric HB and HCC has been reported in small series. We analyzed national outcomes and changes in donor, recipient, and perioperative factors over time that may contribute to survival differences. ...
poorly differentiated hepatocellular carcinomaMacroscopically, hepatoblastomas are grayish or brownish nodules (up to 1.5cm in diameter) often associated with hemorrhagic cysts, vascular lakes, or areas of necrosis. Hepatoblastoma may have the appearance of a large hemorrhagic cyst with a thick, grayish ...
Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int J Cancer. 2005;114:209–18. Article CAS PubMed Google Scholar Li YY, Mukaida N. Pathophysiological roles of Pim-3 kinase in ...