Scheiblauer, H. et al. Performance evaluation of 70 hepatitis B virus (HBV) surface antigen (HBsAg) assays from around the world by a geographically diverse panel with an array of HBV genotypes and HBsAg subtypes.Vox Sang.98, 403–414 (2010). ArticleCASPubMedPubMed CentralGoogle Scholar Che...
7.3% of patients had advanced cirrhosis, and developed AKI following an episode of hematemesis, presumably due to ischemic acute tubular necrosis. 6.5% were associated with hepatic encephalopathy including the hepatorenal syndrome. Decompensated liver disease, history of intravenous drug abuse, diabetes ...
Insights into the immunopathogenesis of chronic HBV infections are fundamental in the quest for novel treatment approaches aimed at a functional cure. While much is known about the ineffective HBV-specific T-cell responses that characterise persistent HBV replication, B cells have been left largely und...
Nadkarni GN, Patel A, Simoes PK et al (2016) Dialysis-requiring acute kidney injury among hospitalized adults with documented hepatitis C Virus infection: a nationwide inpatient sample analysis. J Viral Hepat 23:32–38 CAS PubMed Google Scholar Lopes JA, Fernandes J, Jorge S, Neves J, Antu...
60–80% of patients with acute hepatitis C develop the chronic form when the virus overcomes host innate and adaptive immune defenses [[1], [2], [3], [4]]. HCV can be classified into seven confirmed genotypes and 67 subtypes [5]. These genotypes lead to differential prognosis of ...
After acute HBV infection, chronic infection (defined by HBsAg persistence for more than 6 months) develops in > 90% of infants born to infected mothers positive for HBeAg, in approximately 30% of children infected between ages 1 and 4 years, and in ≤ 5% of adults [19]. HBeAg(−...
Based on our studies, it is feasible that infection of lymphocyte populations during acute infection leads to a susceptibility to Fas-mediated cell death, and ultimately, a skewed or inadequate response to HCV infection. This might permit impaired clearance of virally infected cell populations, highe...
Several genome-wide association studies have demonstrated that host SNPs near the IL28B gene are associated with SVR to the treatment with peginterferon alfa and ribavirin in chronic hepatitis C patients [16–18]. These SNPs are also associated with spontaneous clearance of HCV in acute HCV infecti...
Patients who resolve acute HBV infection have a robust, HBV-specific T cell response with both CD4+ and CD8+ T cells essentially participating. These cells produce antiviral cytokines and provide co-stimulation to B cells. B cells produce anti-HBs, which clear antigens and viruses from the ...
Several genome-wide association studies have demonstrated that host SNPs near the IL28B gene are associated with SVR to the treatment with peginterferon alfa and ribavirin in chronic hepatitis C patients [16–18]. These SNPs are also associated with spontaneous clearance of HCV in acute HCV infecti...