The repertoire of IgG antibody responses to infection and vaccination varies depending on the characteristics of the immunogen and the ability of the host to mount a protective immune response. Chronic hepatitis B virus (HBV) infections are marked by persistent infection and immune tolerance to vaccin...
IgA, IgG, IgM Immunoglobulins A, G and M (respectively) κ-RF Kappa-Rheumatoid factor MGN Membranous glomerulonephritis MPGN Membranoproliferative (Mesangiocapillary) glomerulonephritis mTOR Mammalian target of rapamycin NHL Non-Hodgkin lymphoma NODAT New-onset diabetes after transplantation (Post-transplan...
et al. HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations. Leukemia 20, 1145–1154 (2006). 16. Uhlen, M. et al. Tissue-based map of the human proteome. Science (80-. ). 347, 1260419 (2015). 17. Mouquet, H. et...
In ongoing HBV infection, anti-HBc is detected together with HBsAg. While HBsAg may disappear, anti-HBc IgG commonly persists for life even in “resolved” HBV infection [22], probably due to the persistence of HBV in the form of cccDNA and low levels of core antigen production stimulating ...
To this extent, we sequenced IgG transcripts from 500,000 total B cells on the day of and 7 days following each vaccine to gain insight into total repertoire dynamics. Cell sorting was also performed to enrich for vaccine-specific cells and sequencing these enabled generation of a vaccine-...
All these antibodies are of the IgG1 isotype. Name recognizing epitope in E1 represented by aa region IGH 200 aa 212-226 IGH 201 aa 212-226 (ECACC accession number 98031216) IGH 202 aa 212-226 IGH 204 aa 212-226 IGH 207 aa 307-326 (ECACC accession number 98031214) IGH 209 aa 307...
Antibodies cross-reactive to pathogens and autoantigens are considered pivotal in both infection control and accompanying autoimmunity. However, the pathogenic roles of autoantibodies largely remain elusive without a priori knowledge of disease-specific