Thus, the administration of IVIg containing anti‐HBc to children with immune‐compromising conditions may complicate the interpretation of hepatitis B serologic testing in that a positive anti‐HBc test may represent passive transfer of antibody from IVIg or may indicate resolved or chronic hepatitis ...
People with positive HBsAg are infectious and can transmit the virus to others. The IgM subclass of antibody to the hepatitis B core antigen (IgM anti-HBc) indicates acute infection while total IgG anti-HBc is a nonspecific marker of infection which can indicate acute, chronic, or resolved ...
Unfortunately, there are sufficient exceptions to the latter interpretation (in particular a mutation to the pre‐core gene that results in the absence of serum HBeAg despite active viral replication and viremia) that all body fluids from an HBsAg positive individual regardless of their HBeAg/anti‐...
Introduction It has been estimated that from 2013 to 2016 approximately 4.1 million people in the US were hepatitis C virus (HCV) antibody–positive, indicating past exposure, and that of these, approximately 2.4 million had active infection.1 Persons born between 1945 and 1965 were estimated to...
Nearly 60 million people worldwide are infected with Hepatitis C Virus (HCV), a bloodborne pathogen which leads to liver cirrhosis and increases the risk of hepatocellular carcinoma. Those with limited access to healthcare resources, such as injection dr
Th cells and their cytokines play regulatory roles during multiple stages of humoral immunity, including B cell development, differentiation, and antibody production [37]. We observed a significant positive correlation between anti-HBs antibodies and the proportion of Th2 cells at week 24 in the ove...
For instance, we used a structured data collection checklist and regular communication with the hospital staff working at the serology laboratory. HBsAg and anti HCV positive clients’ serum was rechecked using ELISA by Amhara Public Health Institute referral laboratory in Bahir Dar. Finally, we ...
It is worth mentioning that only a couple of countries reported on no, or even a negative impact of guidelines on the treatment accessibility for PWID, whereas more than half of them reported their positive impact across all the examined years, particularly all those presenting any kind of ...
However, when primate studies were performed, discrepant HBsAg suppressive effects were noted when comparing HBeAg-positive and HBeAg-negative primates. A single dose of ARC-520 led to 2.7 log HBsAg reduction in HBeAg-positive primates, whereas the reduction was only 0.9 log in HBeAg-negative ...
Table 2.Interpretation of hepatitis B virus core antibody result Empty CellSusceptible to InfectionImmune from VaccinationImmune, past InfectionChronic InfectionAcute Infection Anti-HBcNegativeNegativePositivePositivePositive View article Infectious diseases ...